Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.48 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.48 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | EFNA1 | P20827 | 1/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.41 |
| ▸ | DHCR24 | Q15392 | 4/20 | 0.39 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.37 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3225968 | 0.84 | PTPN1 (0.46) | GPBAR1EPHA2AKR1B10AKR1B1EFNA1 | |
| SCHEMBL9883783 | 0.78 | CDC25A (0.44) | GPBAR1EPHA2AKR1B10AKR1B1EFNA1 | |
| SCHEMBL9010567 | 0.78 | CDC25A (0.59) | GPBAR1EPHA2AKR1B10AKR1B1EFNA1 | |
| SCHEMBL2609727 | 0.78 | CDC25A (0.59) | GPBAR1EPHA2AKR1B10AKR1B1EFNA1 | |
| SCHEMBL9883785 | 0.78 | CDC25A (0.59) | GPBAR1EPHA2AKR1B10AKR1B1EFNA1 | |
| SCHEMBL4738790 | 0.78 | GPBAR1 (0.68) | GPBAR1EPHA2AKR1B10AKR1B1EFNA1 | |
| SCHEMBL6690597 | 0.76 | CDC25A (0.48) | GPBAR1EPHA2AKR1B10AKR1B1EFNA1 | |
| SCHEMBL8502677 | 0.76 | CDC25A (0.48) | GPBAR1EPHA2AKR1B10AKR1B1EFNA1 | |
| SCHEMBL14208292 | 0.76 | CDC25A (0.46) | DHCR24VDRCDC25A | |
| SCHEMBL5020106 | 0.76 | CDC25A (0.46) | DHCR24VDRCDC25A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853274-B1 | 2-METHYLENE-19-NOR- (20S-24S) - 1ALPHA, 25-DIHYDROXYVITAMINE-D2 | WISCONSIN ALUMNI RES FOUND (US) | 2013-01-23 | — | — | EP | disclosed |