Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 16/20 | 0.51 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | RBP4 | P02753 | 1/20 | 0.46 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL912438 | 0.89 | MGLL (0.54) | MGLLFAAH | |
| SCHEMBL911859 | 0.89 | MGLL (0.58) | MGLLFAAHSLC6A7 | |
| SCHEMBL912124 | 0.88 | SLC6A7 (0.59) | MGLLFAAHSLC6A7 | |
| SCHEMBL911143 | 0.85 | MGLL (0.51) | MGLLFAAHRBP4SLC6A7 | |
| SCHEMBL911992 | 0.85 | MGLL (0.51) | MGLLFAAHRBP4 | |
| SCHEMBL912527 | 0.85 | MGLL (0.49) | MGLLFAAHRBP4 | |
| SCHEMBL912740 | 0.85 | MGLL (0.51) | MGLLFAAHSLC6A7 | |
| SCHEMBL912403 | 0.85 | MGLL (0.51) | MGLLFAAHSLC6A7 | |
| SCHEMBL912342 | 0.85 | MGLL (0.53) | MGLLFAAHRBP4SLC6A7 | |
| SCHEMBL912282 | 0.84 | MGLL (0.59) | MGLLFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |
| EP-2421825-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-01 | — | — | EP | disclosed |
| US-8362000-B2 | Azetidinyl diamides as monoacylglycerol lipase inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2013-01-29 | — | — | US | disclosed |