Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MGLL | Q99685 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 4/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
| ▸ | ACACA | Q13085 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL911002 | 0.84 | MAPT (0.60) | LMNAMAPTPOLBALDH1A1L3MBTL1 | |
| SCHEMBL912106 | 0.83 | LMNA (0.52) | LMNAMAPTPOLBALDH1A1L3MBTL1 | |
| SCHEMBL912139 | 0.76 | MGLL (0.55) | POLBMGLLPARP1 | |
| SCHEMBL911090 | 0.76 | MGLL (0.55) | POLBMGLLPARP1 | |
| SCHEMBL911729 | 0.75 | MGLL (0.66) | POLBMGLLPARP1ACACBACACA | |
| SCHEMBL6840249 | 0.75 | MGLL (0.57) | POLBL3MBTL1MGLL | |
| SCHEMBL14876946 | 0.75 | MGLL (0.57) | LMNAPOLBALDH1A1L3MBTL1MGLL | |
| SCHEMBL911978 | 0.74 | MGLL (0.61) | POLBMGLLKDM4ECNR1CNR2 | |
| SCHEMBL911746 | 0.74 | MGLL (0.51) | POLBALDH1A1L3MBTL1MGLLTDP1 | |
| SCHEMBL911577 | 0.74 | MGLL (0.69) | LMNAPOLBALDH1A1L3MBTL1MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |
| EP-2421825-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-01 | — | — | EP | disclosed |
| US-8362000-B2 | Azetidinyl diamides as monoacylglycerol lipase inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2013-01-29 | — | — | US | disclosed |