SCHEMBL146481

SCHEMBL146481

O=C(c1ccccc1)c1cc(Cl)cc(Br)c1O

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.51
MAPT P10636 4/20 0.48
CNR2 P34972 2/20 0.47
CNR1 P21554 1/20 0.47
ALDH1A1 P00352 4/20 0.46
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
BCL2 P10415 1/20 0.46
MCL1 Q07820 1/20 0.46
MAPK1 P28482 1/20 0.46
GFER P55789 1/20 0.46
AKR1C3 P42330 2/20 0.46
AKR1C4 P17516 1/20 0.46
AKR1C2 P52895 1/20 0.46
AKR1C1 Q04828 1/20 0.46
POLB P06746 1/20 0.46
MITF O75030 1/20 0.46
HSP90AA1 P07900 1/20 0.46
HTT P42858 1/20 0.46
ATM Q13315 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5962843 0.83 MEN1 (0.56) TP53MAPTCNR2CNR1ALDH1A1
SCHEMBL29131794 0.83 MEN1 (0.53) TP53MAPTALDH1A1MEN1KMT2A
SCHEMBL10701348 0.83 AKR1C3 (0.61) MAPTALDH1A1MEN1KMT2ABCL2
SCHEMBL11710855 0.83 AKR1C2 (0.61) MAPTCNR2CNR1ALDH1A1BCL2
SCHEMBL141548 0.82 RECQL (0.55) TP53MAPTALDH1A1MAPK1AKR1C3
SCHEMBL11342058 0.81 BCL2 (0.58) MAPTALDH1A1MEN1KMT2ABCL2
SCHEMBL11293046 0.80 MAPT (0.53) MAPTCNR2CNR1ALDH1A1BCL2
SCHEMBL1638886 0.80 BCL2 (0.50) MAPTALDH1A1MEN1KMT2ABCL2
SCHEMBL1560518 0.79 MEN1 (0.51) MAPTALDH1A1MEN1KMT2ABCL2
SCHEMBL2875670 0.79 TP53 (0.65) TP53MAPTCNR2ALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2613819-B2 LUBRICIOUS COATINGS FOR MEDICAL DEVICES BIOINTERACTIONS LTD (GB) 2020-11-25 EP claimed
EP-2613819-B1 LUBRICIOUS COATINGS FOR MEDICAL DEVICES BIOINTERACTIONS LTD (GB) 2018-01-10 EP claimed
CN-103209717-B Lubricious coatings for medical devices BIOINTERACTIONS LTD 2015-04-08 CN claimed
US-8541498-B2 Lubricious coatings for medical devices BIOINTERACTIONS LTD. (GB) 2013-09-24 US claimed
EP-2613819-A1 Lubricious coatings for medical devices Biointeractions Ltd. (GB) 2013-07-17 EP claimed
WO-2012032283-A1 Lubricious coatings for medical devices BIOINTERACTIONS LTD (GB) 2012-03-15 WO claimed
US-20120059111-A1 LUBRICIOUS COATINGS FOR MEDICAL DEVICES BIOINTERACTIONS LTD. (GB) 2012-03-08 US claimed
EP-2613819-B2 LUBRICIOUS COATINGS FOR MEDICAL DEVICES BIOINTERACTIONS LTD (GB) 2020-11-25 EP disclosed
EP-2613819-B1 LUBRICIOUS COATINGS FOR MEDICAL DEVICES BIOINTERACTIONS LTD (GB) 2018-01-10 EP disclosed
CN-103209717-B Lubricious coatings for medical devices BIOINTERACTIONS LTD 2015-04-08 CN disclosed
US-8541498-B2 Lubricious coatings for medical devices BIOINTERACTIONS LTD. (GB) 2013-09-24 US disclosed
EP-2613819-A1 Lubricious coatings for medical devices Biointeractions Ltd. (GB) 2013-07-17 EP disclosed
WO-2012032283-A1 Lubricious coatings for medical devices BIOINTERACTIONS LTD (GB) 2012-03-15 WO disclosed
US-20120059111-A1 LUBRICIOUS COATINGS FOR MEDICAL DEVICES BIOINTERACTIONS LTD. (GB) 2012-03-08 US disclosed