Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.56 |
| ▸ | TDO2 | P48775 | 2/20 | 0.56 |
| ▸ | ACP3 | P15309 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14648181 | 0.96 | IDO1 (0.49) | IDO1TDO2ACP3GAACES2 | |
| SCHEMBL14648173 | 0.87 | ACP3 (0.48) | IDO1TDO2ACP3CES2MEN1 | |
| SCHEMBL1131746 | 0.82 | ESR1 (0.49) | KMT2AALDH1A1CYP3A4 | |
| SCHEMBL14648279 | 0.78 | ACP3 (0.46) | IDO1TDO2ACP3KMT2AALDH1A1 | |
| SCHEMBL14648295 | 0.77 | MEN1 (0.42) | MEN1KMT2ANPSR1L3MBTL1EPHX1 | |
| SCHEMBL14938033 | 0.77 | ALDH1A1 (0.43) | GAAMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL14648207 | 0.77 | HDAC4 (0.45) | IDO1TDO2CES2CYP2C9 | |
| SCHEMBL14648171 | 0.77 | NPC1 (0.42) | GAAMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL27990971 | 0.76 | ESR1 (0.39) | CES2MEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL28922018 | 0.76 | HTR2A (0.44) | ACP3CES2MEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2906970-B1 | HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS WITH REDUCED TACK | NOVARTIS AG (CH) | 2016-11-23 | — | — | EP | claimed |
| EP-2906970-A1 | HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS WITH REDUCED TACK | Novartis AG (CH) | 2015-08-19 | — | — | EP | claimed |
| CN-104620137-A | High refractive index ophthalmic device materials with reduced tack | NOVARTIS AG | 2015-05-13 | — | — | CN | claimed |
| WO-2014062151-A1 | HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS WITH REDUCED TACK | NOVARTIS AG (CH) | 2014-04-24 | — | — | WO | claimed |
| US-20130030079-A1 | HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS WITH REDUCED TACK | NOVARTIS AG (CH) | 2013-01-31 | — | — | US | claimed |
| US-8362177-B1 | High refractive index ophthalmic device materials with reduced tack | NOVARTIS AG (CH) | 2013-01-29 | — | — | US | claimed |
| EP-2906970-B1 | HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS WITH REDUCED TACK | NOVARTIS AG (CH) | 2016-11-23 | — | — | EP | disclosed |
| EP-2906970-A1 | HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS WITH REDUCED TACK | Novartis AG (CH) | 2015-08-19 | — | — | EP | disclosed |
| CN-104620137-A | High refractive index ophthalmic device materials with reduced tack | NOVARTIS AG | 2015-05-13 | — | — | CN | disclosed |
| WO-2014062151-A1 | HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS WITH REDUCED TACK | NOVARTIS AG (CH) | 2014-04-24 | — | — | WO | disclosed |
| US-20130030079-A1 | HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS WITH REDUCED TACK | NOVARTIS AG (CH) | 2013-01-31 | — | — | US | disclosed |
| US-8362177-B1 | High refractive index ophthalmic device materials with reduced tack | NOVARTIS AG (CH) | 2013-01-29 | — | — | US | disclosed |