Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 1.00 |
| ▸ | NPC1 | O15118 | 7/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 0.77 |
| ▸ | TP53 | P04637 | 2/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 2/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | CASP3 | P42574 | 1/20 | 0.63 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2175908 | 0.87 | RAB9A (0.77) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL28799002 | 0.84 | SMN1; SMN2 (0.72) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL17712431 | 0.83 | SMN1; SMN2 (0.71) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL2179411 | 0.82 | NPC1 (0.69) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL8556554 | 0.81 | KMT2A (0.75) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL13210613 | 0.81 | RAB9A (0.68) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL14316971 | 0.79 | CA1 (0.78) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL15006448 | 0.78 | SMN1; SMN2 (0.64) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL7348805 | 0.76 | MEN1 (0.71) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL8132955 | 0.76 | SMN1; SMN2 (0.69) | RAB9ANPC1SMN1; SMN2MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130022629-A1 | Modulators of Immunoinhibitory Receptor PD-1, and Methods of Use Thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2013-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130022629-A1 | Modulators of Immunoinhibitory Receptor PD-1, and Methods of Use Thereof | CD274, PDCD1LG2, PDCD1 | RAB9A 2271/4885NPC1 3823/4885SMN1; SMN2 4661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.