Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.72 |
| ▸ | RAB9A | P51151 | 8/20 | 0.72 |
| ▸ | NPC1 | O15118 | 7/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | CASP3 | P42574 | 1/20 | 0.60 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.58 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27877118 | 0.84 | SMN1; SMN2 (0.51) | SMN1; SMN2RAB9ANPC1KDM4EGAA | |
| SCHEMBL14648355 | 0.84 | RAB9A (1.00) | SMN1; SMN2RAB9ANPC1KDM4EGAA | |
| SCHEMBL2664519 | 0.84 | SMN1; SMN2 (0.67) | SMN1; SMN2RAB9ANPC1KDM4ECASP3 | |
| P-Xylene SCHEMBL8779368 | 0.84 | SMN1; SMN2 (0.50) | SMN1; SMN2RAB9ANPC1KDM4EGAA | |
| SCHEMBL27877036 | 0.82 | LMNA (0.62) | SMN1; SMN2RAB9ANPC1KDM4EGAA | |
| SCHEMBL12039939 | 0.81 | NPC1 (0.48) | SMN1; SMN2RAB9ANPC1KDM4EGAA | |
| SCHEMBL11051554 | 0.80 | CA1 (0.65) | SMN1; SMN2RAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL16589785 | 0.79 | LMNA (0.51) | SMN1; SMN2RAB9ANPC1KDM4EGAA | |
| SCHEMBL27860322 | 0.77 | TP53 (0.55) | SMN1; SMN2RAB9ANPC1KDM4EGAA | |
| SCHEMBL14316971 | 0.77 | CA1 (0.78) | SMN1; SMN2RAB9ANPC1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102532126-B | 2-substituted-4-chloro-5-[5-subtsituted amino-2-(1,3,4-thiadiazole)-sulfydryl]-3(2H)- pyridazinone derivatives, and preparation method and application thereof | UNIV GUIZHOU | 2014-06-18 | — | — | CN | disclosed |
| CN-102532126-A | 2-substituted-4-chloro-5-[5-subtsituted amino-2-(1,3,4-thiadiazole)-sulfydryl]-3(2H)- pyridazinone derivatives, and preparation method and application thereof | UNIV GUIZHOU | 2012-07-04 | — | — | CN | disclosed |