Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 5/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
| ▸ | RORA | P35398 | 1/20 | 0.34 |
| ▸ | RORB | Q92753 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2222576 | 0.87 | MAPT (0.44) | MAPTKDM4EPOLBNPSR1L3MBTL1 | |
| SCHEMBL12517306 | 0.87 | MAPT (0.52) | MAPTKDM4EPOLBNPSR1L3MBTL1 | |
| SCHEMBL2225036 | 0.85 | MAPT (0.50) | MAPTKDM4EPOLBNPSR1L3MBTL1 | |
| SCHEMBL2222572 | 0.84 | MAPT (0.43) | MAPTKDM4EPOLBNPSR1L3MBTL1 | |
| SCHEMBL2224108 | 0.82 | L3MBTL1 (0.44) | MAPTKDM4EPOLBNPSR1L3MBTL1 | |
| SCHEMBL2221685 | 0.82 | MAPT (0.50) | MAPTKDM4EPOLBNPSR1L3MBTL1 | |
| SCHEMBL2224063 | 0.82 | MAPT (0.48) | MAPTKDM4EPOLBNPSR1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL2221555 | 0.81 | MAPT (0.49) | MAPTKDM4EPOLBNPSR1L3MBTL1 | |
| SCHEMBL2225299 | 0.81 | MAPT (0.42) | MAPTKDM4EPOLBNPSR1L3MBTL1 | |
| SCHEMBL2224662 | 0.81 | MAPT (0.52) | MAPTKDM4EPOLBNPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130023541-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | GLAXO GROUP LIMITED | 2013-01-24 | — | — | US | disclosed |
| US-20130023541-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | GLAXO GROUP LIMITED | 2013-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130023541-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | KCNB1, KCNB2, SCNN1B | MAPT 1880/4885KDM4E 3172/4885POLB 2987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.