Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RBP4 | P02753 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14655213 | 1.00 | KDM4E (0.47) | KDM4ERAB9ANPC1KMT2AL3MBTL1 | |
| SCHEMBL14655212 | 1.00 | KDM4E (0.47) | KDM4ERAB9ANPC1KMT2AL3MBTL1 | |
| SCHEMBL14964290 | 0.82 | KDM4E (0.46) | KDM4ERAB9ANPC1KMT2AL3MBTL1 | |
| SCHEMBL14655348 | 0.81 | KDM4E (0.48) | KDM4ERAB9ANPC1KMT2AL3MBTL1 | |
| SCHEMBL14964189 | 0.81 | KDM4E (0.46) | KDM4ERAB9ANPC1KMT2AL3MBTL1 | |
| SCHEMBL14655219 | 0.80 | KDM4E (0.47) | KDM4ERAB9ANPC1KMT2AL3MBTL1 | |
| SCHEMBL14964178 | 0.79 | KDM4E (0.53) | KDM4ERAB9ANPC1KMT2AL3MBTL1 | |
| SCHEMBL14964195 | 0.79 | KDM4E (0.46) | KDM4ERAB9ANPC1KMT2AL3MBTL1 | |
| SCHEMBL19150844 | 0.78 | L3MBTL1 (0.48) | KDM4ERAB9ANPC1KMT2AL3MBTL1 | |
| SCHEMBL8965608 | 0.74 | KDM4E (0.44) | KDM4ERAB9ANPC1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450354-B2 | Substituted imidazo[1,2-b]pyridazine derivatives, pharmaceutical compositions, and methods of use as β-secretase inhibitors | HIGH POINT PHARMACEUTICALS, LLC (US) | 2013-05-28 | — | — | US | claimed |
| US-8450342-B2 | Perharidines as CDK inhibitors | CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE (FR) | 2013-05-28 | — | — | US | disclosed |
| US-8450354-B2 | Substituted imidazo[1,2-b]pyridazine derivatives, pharmaceutical compositions, and methods of use as β-secretase inhibitors | HIGH POINT PHARMACEUTICALS, LLC (US) | 2013-05-28 | — | — | US | disclosed |
| US-8450351-B2 | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase | INCYTE CORPORATION (US) | 2013-05-28 | — | — | US | disclosed |
| EP-2549874-A1 | SUBSTITUTED IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS BETA-SECRETASE INHIBITORS | High Point Pharmaceuticals, LLC (US) | 2013-01-30 | — | — | EP | disclosed |