Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | RBP4 | P02753 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14964189 | 0.84 | KDM4E (0.46) | KDM4ERAB9ANPC1KMT2AL3MBTL1 | |
| SCHEMBL14655212 | 0.82 | KDM4E (0.47) | KDM4ERAB9ANPC1KMT2AL3MBTL1 | |
| SCHEMBL14655211 | 0.82 | KDM4E (0.47) | KDM4ERAB9ANPC1KMT2AL3MBTL1 | |
| SCHEMBL14655213 | 0.82 | KDM4E (0.47) | KDM4ERAB9ANPC1KMT2AL3MBTL1 | |
| SCHEMBL14964178 | 0.77 | KDM4E (0.53) | KDM4ERAB9ANPC1KMT2AL3MBTL1 | |
| SCHEMBL14655348 | 0.73 | KDM4E (0.48) | KDM4ERAB9ANPC1KMT2AL3MBTL1 | |
| SCHEMBL14655219 | 0.73 | KDM4E (0.47) | KDM4ERAB9ANPC1KMT2AL3MBTL1 | |
| SCHEMBL12891188 | 0.72 | PTGS1 (0.41) | KDM4ERAB9ANPC1KMT2AL3MBTL1 | |
| SCHEMBL14964195 | 0.72 | KDM4E (0.46) | KDM4ERAB9ANPC1KMT2AL3MBTL1 | |
| SCHEMBL19150844 | 0.71 | L3MBTL1 (0.48) | KDM4ERAB9ANPC1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450354-B2 | Substituted imidazo[1,2-b]pyridazine derivatives, pharmaceutical compositions, and methods of use as β-secretase inhibitors | HIGH POINT PHARMACEUTICALS, LLC (US) | 2013-05-28 | — | — | US | disclosed |