Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 1/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | VNN1 | O95497 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 2/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 2/20 | 0.32 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14655486 | 0.80 | DPP4 (0.44) | DPP8DPP7 | |
| SCHEMBL14655514 | 0.80 | DPP4 (0.44) | DPP8DPP7 | |
| SCHEMBL29359207 | 0.80 | SPR (0.47) | SPRDPP8DPP7RXFP1VNN1 | |
| SCHEMBL22488585 | 0.80 | SPR (0.47) | SPRDPP8DPP7RXFP1VNN1 | |
| SCHEMBL27897406 | 0.77 | SPR (0.48) | SPRDPP8DPP7RXFP1VNN1 | |
| SCHEMBL14655504 | 0.77 | DPP4 (0.41) | DPP7 | |
| SCHEMBL4218523 | 0.76 | SPR (0.47) | SPRDPP8DPP7RXFP1VNN1 | |
| SCHEMBL4550272 | 0.74 | SPR (0.46) | SPRDPP8DPP7RXFP1VNN1 | |
| SCHEMBL18312206 | 0.74 | SPR (0.41) | SPRDPP8DPP7RXFP1VNN1 | |
| SCHEMBL18701882 | 0.71 | SPR (0.43) | SPRRXFP1VNN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518945-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2013-08-27 | — | — | US | claimed |
| EP-2550273-A2 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2013-01-30 | — | — | EP | claimed |
| US-8518945-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2013-08-27 | — | — | US | disclosed |