Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 1/20 | 0.47 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | VNN1 | O95497 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | UBE2N | P61088 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 2/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22488585 | 1.00 | SPR (0.47) | SPRDPP8DPP7RXFP1VNN1 | |
| SCHEMBL18312206 | 0.89 | SPR (0.41) | SPRDPP8DPP7RXFP1VNN1 | |
| SCHEMBL28692543 | 0.88 | RXFP1 (0.49) | RXFP1SMN1; SMN2UBE2NNAMPTCRHBP | |
| SCHEMBL27897406 | 0.85 | SPR (0.48) | SPRDPP8DPP7RXFP1VNN1 | |
| SCHEMBL4218523 | 0.83 | SPR (0.47) | SPRDPP8DPP7RXFP1VNN1 | |
| SCHEMBL22010646 | 0.82 | SPR (0.34) | SPRRXFP1SMN1; SMN2 | |
| SCHEMBL4550272 | 0.82 | SPR (0.46) | SPRDPP8DPP7RXFP1VNN1 | |
| SCHEMBL14655320 | 0.80 | SPR (0.42) | SPRDPP8DPP7RXFP1VNN1 | |
| SCHEMBL15448194 | 0.79 | CYP2D6 (0.47) | SMN1; SMN2GAA | |
| SCHEMBL1104719 | 0.79 | CYP2D6 (0.47) | SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116761801-A | Heterocyclic compounds having protein kinase inhibitory activity, pharmaceutical compositions containing the same, and methods of preparing and using the same | 四川科伦博泰生物医药股份有限公司 | 2023-09-15 | — | — | CN | disclosed |
| EP-3962484-A1 | INHIBITORS OF RAF KINASES | Kinnate Biopharma Inc. (US) | 2022-03-09 | — | — | EP | disclosed |
| EP-3941922-A1 | INHIBITORS OF RAF KINASES | Kinnate Biopharma Inc. (US) | 2022-01-26 | — | — | EP | disclosed |