Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 15/20 | 0.36 |
| ▸ | MST1R | Q04912 | 12/20 | 0.36 |
| ▸ | KDR | P35968 | 9/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14655593 | 0.92 | GRIN3B (0.37) | METMST1RKDRDGAT1 | |
| SCHEMBL14655557 | 0.87 | PTPN1 (0.34) | DGAT1PTPN1 | |
| SCHEMBL14656033 | 0.84 | SIRT2 (0.34) | DGAT1 | |
| SCHEMBL2380301 | 0.81 | JAK1 (0.39) | METMST1RKDR | |
| SCHEMBL14655329 | 0.79 | DGAT1 (0.43) | DGAT1PTPN1 | |
| SCHEMBL2380160 | 0.79 | GRIN3B (0.37) | METMST1RKDRDGAT1 | |
| SCHEMBL2380151 | 0.79 | GRIN3B (0.37) | METMST1RKDRDGAT1 | |
| SCHEMBL14795118 | 0.77 | DGAT1 (0.34) | DGAT1PTPN1 | |
| SCHEMBL14655487 | 0.76 | DGAT1 (0.38) | DGAT1PTPN1 | |
| SCHEMBL14655373 | 0.75 | DGAT1 (0.36) | DGAT1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518945-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2013-08-27 | — | — | US | disclosed |
| EP-2550273-A2 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2013-01-30 | — | — | EP | disclosed |