Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 8/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | F11 | P03951 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14795118 | 0.85 | DGAT1 (0.34) | DGAT1PTPN1KLKB1MAPTPDE10A | |
| SCHEMBL14738023 | 0.84 | DGAT1 (0.42) | DGAT1PTPN1KLKB1MAPTF11 | |
| SCHEMBL14655557 | 0.83 | PTPN1 (0.34) | DGAT1PTPN1KLKB1MAPT | |
| SCHEMBL14795236 | 0.82 | DGAT1 (0.33) | DGAT1PTPN1KLKB1MAPTPDE10A | |
| SCHEMBL14738170 | 0.81 | DGAT1 (0.37) | DGAT1PTPN1KLKB1MAPT | |
| SCHEMBL14795223 | 0.81 | CYP3A4 (0.37) | DGAT1PTPN1KLKB1MAPT | |
| SCHEMBL14655938 | 0.80 | DGAT1 (0.36) | DGAT1KLKB1MAPT | |
| SCHEMBL12145882 | 0.80 | KLKB1 (0.40) | DGAT1PTPN1KLKB1MAPT | |
| SCHEMBL14795136 | 0.80 | DGAT1 (0.32) | DGAT1 | |
| SCHEMBL14795133 | 0.80 | MAPT (0.35) | DGAT1PTPN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518945-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2013-08-27 | — | — | US | disclosed |
| EP-2550273-A2 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2013-01-30 | — | — | EP | disclosed |
| CN-102803265-A | Pyrrolopyrazine kinase inhibitors | HOFFMANN LA ROCHE | 2012-11-28 | — | — | CN | disclosed |