Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TARDBP | Q13148 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31614119 | 0.68 | SMN1; SMN2 (0.34) | GAASMN1; SMN2KMT2A | |
| SCHEMBL6855190 | 0.67 | NCF1 (0.48) | L3MBTL1GAA | |
| SCHEMBL15986798 | 0.66 | NCF1 (0.42) | L3MBTL1GAASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL30412623 | 0.66 | GNAI3 (0.50) | L3MBTL1GAASMN1; SMN2 | |
| SCHEMBL12617789 | 0.66 | NCF1 (0.31) | SMN1; SMN2 | |
| SCHEMBL23405541 | 0.64 | EPHX1 (0.38) | GAASMN1; SMN2 | |
| SCHEMBL19544407 | 0.64 | CYP1A2 (0.46) | L3MBTL1 | |
| SCHEMBL23110427 | 0.63 | SMN1; SMN2 (0.44) | L3MBTL1SMN1; SMN2KMT2A | |
| SCHEMBL15716950 | 0.62 | BCHE (0.34) | SMN1; SMN2 | |
| SCHEMBL1479904 | 0.62 | GNAI3 (0.50) | L3MBTL1KMT2ATARDBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2550273-A2 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2013-01-30 | — | — | EP | disclosed |