Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 9/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14738023 | 0.89 | DGAT1 (0.42) | DGAT1KLKB1MAPTALKBH1NPC1 | |
| SCHEMBL12145882 | 0.87 | KLKB1 (0.40) | DGAT1KLKB1MAPTPTPN1 | |
| SCHEMBL1352880 | 0.86 | DGAT1 (0.42) | DGAT1KLKB1MAPTNPC1PTPN1 | |
| SCHEMBL29936480 | 0.86 | DGAT1 (0.42) | DGAT1KLKB1MAPTNPC1PTPN1 | |
| SCHEMBL12301307 | 0.86 | KLKB1 (0.36) | DGAT1KLKB1MAPTNPC1PTPN1 | |
| SCHEMBL14795161 | 0.84 | DGAT1 (0.47) | DGAT1KLKB1MAPTPTPN1 | |
| SCHEMBL14795206 | 0.84 | KLKB1 (0.36) | DGAT1KLKB1MAPT | |
| SCHEMBL14795117 | 0.84 | DGAT1 (0.36) | DGAT1KLKB1MAPTPTPN1 | |
| SCHEMBL14655489 | 0.84 | DGAT1 (0.35) | DGAT1KLKB1MAPT | |
| SCHEMBL1351068 | 0.83 | DGAT1 (0.40) | DGAT1KLKB1MAPTALKBH1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-02-22 | — | — | EP | disclosed |
| EP-2763990-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| US-8658646-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LAROCHE INC. (US) | 2014-02-25 | — | — | US | disclosed |
| WO-2013030138-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |
| US-20130059834-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN-LA ROCHE INC. | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059834-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | SYK, ZAP70, JAK1 | DGAT1 4426/4885KLKB1 1881/4885MAPT 3736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.