Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 8/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14795117 | 0.89 | DGAT1 (0.36) | DGAT1KLKB1MAPT | |
| SCHEMBL14655267 | 0.88 | DGAT1 (0.34) | DGAT1KLKB1MAPT | |
| SCHEMBL14738023 | 0.86 | DGAT1 (0.42) | DGAT1KLKB1MAPT | |
| SCHEMBL12145882 | 0.84 | KLKB1 (0.40) | DGAT1KLKB1MAPT | |
| SCHEMBL29936480 | 0.84 | DGAT1 (0.42) | DGAT1KLKB1MAPT | |
| SCHEMBL1352880 | 0.84 | DGAT1 (0.42) | DGAT1KLKB1MAPT | |
| SCHEMBL12301307 | 0.84 | KLKB1 (0.36) | DGAT1KLKB1MAPT | |
| SCHEMBL14738170 | 0.84 | DGAT1 (0.37) | DGAT1KLKB1MAPT | |
| SCHEMBL14795206 | 0.81 | KLKB1 (0.36) | DGAT1KLKB1MAPT | |
| SCHEMBL14795161 | 0.81 | DGAT1 (0.47) | DGAT1KLKB1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518945-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2013-08-27 | — | — | US | disclosed |
| EP-2550273-A2 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2013-01-30 | — | — | EP | disclosed |