Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 9/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMYD3 | Q9H7B4 | 7/20 | 0.40 |
| ▸ | FAP | Q12884 | 2/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.39 |
| ▸ | PREP | P48147 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14656010 | 0.90 | DPP4 (0.50) | DPP4FAPDPP7DPP8DPP9 | |
| SCHEMBL19981814 | 0.86 | DPP4 (0.55) | DPP4FAPDPP7DPP8DPP9 | |
| SCHEMBL19652203 | 0.85 | MEN1 (0.43) | DPP4MEN1ALDH1A1KMT2A | |
| SCHEMBL15203513 | 0.82 | DPP4 (0.55) | DPP4KMT2ADPP7DPP8DPP9 | |
| SCHEMBL2455912 | 0.81 | DPP4 (0.47) | DPP4DPP8DPP9 | |
| SCHEMBL28132789 | 0.81 | DPP4 (0.47) | DPP4DPP8DPP9 | |
| SCHEMBL2456462 | 0.81 | DPP4 (0.56) | DPP4FAPDPP7DPP8DPP9 | |
| SCHEMBL2456457 | 0.81 | DPP4 (0.56) | DPP4FAPDPP7DPP8DPP9 | |
| SCHEMBL14655953 | 0.81 | DPP4 (0.61) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL14656008 | 0.81 | DPP4 (0.61) | DPP4DPP7DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518945-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2013-08-27 | — | — | US | claimed |
| EP-2550273-A2 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2013-01-30 | — | — | EP | claimed |
| US-8518945-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2013-08-27 | — | — | US | disclosed |