Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 14/20 | 0.47 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.36 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2455912 | 1.00 | DPP4 (0.47) | DPP4DPP8DPP9CHRNB2CHRNA3 | |
| Hydrochloric Acid SCHEMBL14737849 | 0.98 | DPP4 (0.46) | DPP4DPP8DPP9CHRNB2CHRNA3 | |
| Trifluoroacetic Acid SCHEMBL2379272 | 0.89 | DPP4 (0.44) | DPP4DPP8DPP9 | |
| SCHEMBL14656010 | 0.86 | DPP4 (0.50) | DPP4DPP8DPP9JAK2JAK1 | |
| SCHEMBL9901341 | 0.85 | DPP4 (0.50) | DPP4DPP8DPP9HCRTR2 | |
| SCHEMBL14790967 | 0.84 | CHRNB2 (0.52) | DPP4CHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL14655949 | 0.81 | DPP4 (0.53) | DPP4DPP8DPP9 | |
| SCHEMBL15203524 | 0.81 | DPP4 (0.56) | DPP4DPP8DPP9HCRTR2 | |
| SCHEMBL14655442 | 0.80 | DPP4 (0.51) | DPP4DPP8DPP9JAK2JAK1 | |
| SCHEMBL14737248 | 0.80 | DPP4 (0.40) | DPP4DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104024258-B | Pyrrolopyrazine kinase inhibitors | 霍夫曼-拉罗奇有限公司 | 2017-02-15 | — | — | CN | disclosed |
| CN-104024258-A | Pyrrolopyrazine kinase inhibitors | HOFFMANN LA ROCHE | 2014-09-03 | — | — | CN | disclosed |