Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 8/20 | 0.76 |
| ▸ | MAOA | P21397 | 5/20 | 0.76 |
| ▸ | BCHE | P06276 | 1/20 | 0.68 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | KRAS | P01116 | 2/20 | 0.63 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.61 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | CTSL | P07711 | 1/20 | 0.60 |
| ▸ | CTSB | P07858 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14659297 | 1.00 | MAOB (0.76) | MAOBMAOABCHECYP1B1MAPT | |
| SCHEMBL12973292 | 0.90 | POLB (0.68) | MAOBMAOAMAPTMEN1KMT2A | |
| SCHEMBL14659792 | 0.90 | POLB (0.68) | MAOBMAOAMAPTMEN1KMT2A | |
| SCHEMBL6733848 | 0.88 | MAOB (0.85) | MAOBMAOABCHECYP1B1MAPT | |
| SCHEMBL6733854 | 0.88 | MAOB (0.85) | MAOBMAOABCHECYP1B1MAPT | |
| SCHEMBL31326032 | 0.86 | MAOB (1.00) | MAOBMAOABCHECYP1B1MAPT | |
| SCHEMBL10658782 | 0.86 | MAOB (1.00) | MAOBMAOABCHECYP1B1MAPT | |
| SCHEMBL14435873 | 0.86 | MAOB (1.00) | MAOBMAOABCHECYP1B1MAPT | |
| SCHEMBL10658787 | 0.86 | MAOB (1.00) | MAOBMAOABCHECYP1B1MAPT | |
| SCHEMBL9341399 | 0.84 | MAOB (1.00) | MAOBMAOABCHECYP1B1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2772490-B1 | AMINOALKYL-SUBSTITUTED N-THIENYL BENZAMIDE DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2016-04-06 | — | — | EP | disclosed |
| US-9284295-B2 | Tetrahydrobenzothiophene compound | ASTELLAS PHARMA INC. (JP) | 2016-03-15 | — | — | US | disclosed |
| US-9062032-B2 | Aminoalkyl-substituted N-thienylbenzamide derivative | ASTELLAS PHARMA INC. (JP) | 2015-06-23 | — | — | US | disclosed |
| US-9062032-B2 | Aminoalkyl-substituted N-thienylbenzamide derivative | ASTELLAS PHARMA INC. (JP) | 2015-06-23 | — | — | US | disclosed |
| EP-2565190-B1 | TETRAHYDROBENZOTHIOPHENE COMPOUND | ASTELLAS PHARMA INC (JP) | 2015-06-03 | — | — | EP | disclosed |
| US-20150031727-A1 | AMINOALKYL-SUBSTITUTED N-THIENYLBENZAMIDE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2015-01-29 | — | — | US | disclosed |
| US-20150031727-A1 | AMINOALKYL-SUBSTITUTED N-THIENYLBENZAMIDE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2015-01-29 | — | — | US | disclosed |
| US-20140329802-A1 | TETRAHYDROBENZOTHIOPHENE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2014-11-06 | — | — | US | disclosed |
| EP-2772490-A1 | AMINOALKYL-SUBSTITUTED N-THIENYL BENZAMIDE DERIVATIVE | Astellas Pharma Inc. (JP) | 2014-09-03 | — | — | EP | disclosed |
| US-8729068-B2 | Tetrahydrobenzothiophene compound | ASTELLAS PHARMA INC. (JP) | 2014-05-20 | — | — | US | disclosed |
| EP-2565190-A1 | TETRAHYDROBENZOTHIOPHENE COMPOUND | Astellas Pharma Inc. (JP) | 2013-03-06 | — | — | EP | disclosed |
| US-20130053369-A1 | TETRAHYDROBENZOTHIOPHENE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2013-02-28 | — | — | US | disclosed |
| US-20130029973-A1 | TETRAHYDROBENZOTHIOPHENE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2013-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140329802-A1 | TETRAHYDROBENZOTHIOPHENE COMPOUND | SLC34A2, SLC34A1, SLC10A2 | MAOB 2685/4885MAOA 4569/4885BCHE 3068/4885 |
| US-20130029973-A1 | TETRAHYDROBENZOTHIOPHENE COMPOUND | SLC34A2, SLC10A2, SLC34A1 | MAOB 3884/4885MAOA 4809/4885BCHE 3115/4885 |
| US-20130053369-A1 | TETRAHYDROBENZOTHIOPHENE COMPOUND | SLC34A2, SLC34A1, SLC10A2 | MAOB 2685/4885MAOA 4569/4885BCHE 3068/4885 |
| US-20150031727-A1 | AMINOALKYL-SUBSTITUTED N-THIENYLBENZAMIDE DERIVATIVE | SLC34A2, SLC10A2, ALPI | MAOB 2380/4885MAOA 3967/4885BCHE 2242/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.