Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 1/20 | 0.39 |
| ▸ | ARG1 | P05089 | 1/20 | 0.36 |
| ▸ | ARG2 | P78540 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL6632314 | 1.00 | FFAR3 (0.39) | FFAR3ARG1ARG2 | |
| SCHEMBL573927 | 0.98 | — | — | |
| SCHEMBL3325667 | 0.98 | — | — | |
| SCHEMBL697443 | 0.98 | — | — | |
| Water SCHEMBL25175984 | 0.95 | FFAR3 (0.39) | FFAR3ARG1ARG2 | |
| Hydrochloric Acid SCHEMBL17393208 | 0.95 | FFAR3 (0.39) | FFAR3ARG1ARG2 | |
| Hydrochloric Acid SCHEMBL16798066 | 0.95 | FFAR3 (0.39) | FFAR3ARG1ARG2 | |
| Hydrochloric Acid SCHEMBL17393207 | 0.95 | FFAR3 (0.39) | FFAR3ARG1ARG2 | |
| SCHEMBL25372775 | 0.91 | FFAR3 (0.39) | FFAR3ARG1ARG2 | |
| SCHEMBL53553 | 0.91 | FFAR3 (0.39) | FFAR3ARG1ARG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9284295-B2 | Tetrahydrobenzothiophene compound | ASTELLAS PHARMA INC. (JP) | 2016-03-15 | — | — | US | disclosed |
| EP-2565190-B1 | TETRAHYDROBENZOTHIOPHENE COMPOUND | ASTELLAS PHARMA INC (JP) | 2015-06-03 | — | — | EP | disclosed |
| US-20140329802-A1 | TETRAHYDROBENZOTHIOPHENE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2014-11-06 | — | — | US | disclosed |
| US-8729068-B2 | Tetrahydrobenzothiophene compound | ASTELLAS PHARMA INC. (JP) | 2014-05-20 | — | — | US | disclosed |
| EP-2565190-A1 | TETRAHYDROBENZOTHIOPHENE COMPOUND | Astellas Pharma Inc. (JP) | 2013-03-06 | — | — | EP | disclosed |
| US-20130053369-A1 | TETRAHYDROBENZOTHIOPHENE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2013-02-28 | — | — | US | disclosed |
| US-20130029973-A1 | TETRAHYDROBENZOTHIOPHENE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2013-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140329802-A1 | TETRAHYDROBENZOTHIOPHENE COMPOUND | SLC34A2, SLC34A1, SLC10A2 | FFAR3 1514/4885ARG1 2589/4885ARG2 2203/4885 |
| US-20130029973-A1 | TETRAHYDROBENZOTHIOPHENE COMPOUND | SLC34A2, SLC10A2, SLC34A1 | FFAR3 3058/4885ARG1 4695/4885ARG2 4390/4885 |
| US-20130053369-A1 | TETRAHYDROBENZOTHIOPHENE COMPOUND | SLC34A2, SLC34A1, SLC10A2 | FFAR3 1514/4885ARG1 2589/4885ARG2 2203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.