Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | LTA4H | P09960 | 2/20 | 0.52 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.51 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8633541 | 0.94 | ALOX5 (0.66) | ALOX5SMN1; SMN2TDP1LTA4HCYP4F2 | |
| SCHEMBL8633942 | 0.87 | ALOX5 (0.58) | ALOX5TDP1LTA4HDRD2OPRM1 | |
| SCHEMBL1140947 | 0.86 | SMN1; SMN2 (0.55) | ALOX5SMN1; SMN2TDP1LTA4HCYP4F2 | |
| SCHEMBL9324850 | 0.86 | SMN1; SMN2 (0.55) | ALOX5SMN1; SMN2TDP1LTA4HCYP4F2 | |
| SCHEMBL6839565 | 0.85 | KCNH2 (0.64) | ALOX5SMN1; SMN2TDP1LTA4HL3MBTL1 | |
| SCHEMBL22838351 | 0.84 | CA12 (0.54) | ALOX5TDP1LTA4HL3MBTL1DRD2 | |
| Ethyl 3-Phenylpropanoate SCHEMBL304816 | 0.83 | TDP1 (0.75) | ALOX5SMN1; SMN2TDP1CYP4F2CYP4A11 | |
| SCHEMBL9730917 | 0.83 | ALOX5 (0.60) | ALOX5SMN1; SMN2TDP1LTA4HHDAC1 | |
| SCHEMBL5176893 | 0.83 | BCHE (0.57) | ALOX5SMN1; SMN2TDP1LTA4HL3MBTL1 | |
| SCHEMBL14045656 | 0.83 | ALOX5 (0.52) | ALOX5SMN1; SMN2LTA4HABCB1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2734521-A1 | TETRAHYDROPYRIDO-PYRIDINE AND TETRAHYDROPYRIDO-PYRIMIDINE COMPOUNDS AND USE THEREOF AS C5A RECEPTOR MODULATORS | Novartis AG (CH) | 2014-05-28 | — | — | EP | disclosed |
| WO-2013016197-A1 | TETRAHYDROPYRIDO-PYRIDINE AND TETRAHYDROPYRIDO-PYRIMIDINE COMPOUNDS AND USE THEREOF AS C5A RECEPTOR MODULATORS | NOVARTIS AG (CH) | 2013-01-31 | — | — | WO | disclosed |