SCHEMBL14660487

SCHEMBL14660487

CC(C)(C)OC(=O)NCCCOc1ccc(Cl)cc1Cl

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.57
MAPK1 P28482 1/20 0.57
L3MBTL1 Q9Y468 1/20 0.57
IDO1 P14902 2/20 0.57
MAPT P10636 1/20 0.56
HPGD P15428 4/20 0.56
TSHR P16473 3/20 0.56
SMN1; SMN2 Q16637 4/20 0.55
RAB9A P51151 4/20 0.55
CYP1A2 P05177 2/20 0.55
CYP2C19 P33261 2/20 0.55
NPC1 O15118 2/20 0.55
NLRP1 Q9C000 1/20 0.52
ALDH1A1 P00352 2/20 0.50
LMNA P02545 2/20 0.50
CYP3A4 P08684 1/20 0.50
KDM4E B2RXH2 1/20 0.50
CA12 O43570 1/20 0.50
CA1 P00915 1/20 0.50
CA2 P00918 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3453194 0.96 IDO1 (0.60) TP53MAPK1L3MBTL1IDO1MAPT
SCHEMBL9797612 0.88 LMNA (0.64) TP53MAPK1L3MBTL1IDO1MAPT
SCHEMBL4573884 0.88 CA12 (0.51) TP53MAPK1L3MBTL1IDO1SMN1; SMN2
SCHEMBL16593002 0.88 AAK1 (0.61) TP53HPGDTSHRSMN1; SMN2RAB9A
SCHEMBL16593036 0.85 CA12 (0.51) IDO1SMN1; SMN2CYP1A2CYP2C19ALDH1A1
SCHEMBL21601440 0.85 AAK1 (0.49) L3MBTL1IDO1MAPTHPGDSMN1; SMN2
SCHEMBL21601453 0.85 KDM4E (0.54) TP53IDO1HPGDSMN1; SMN2RAB9A
SCHEMBL16939134 0.84 HPGD (0.54) TP53MAPK1L3MBTL1IDO1MAPT
SCHEMBL12409191 0.84 KDM4E (0.62) MAPK1IDO1SMN1; SMN2ALDH1A1LMNA
SCHEMBL21601218 0.84 IDO1 (0.53) MAPK1IDO1HPGDSMN1; SMN2RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3104846-B1 MAO INHIBITORS AND THEIR CONJUGATES AS THERAPEUTICS FOR THE TREATMENT OF BRAIN CANCER UNIV SOUTHERN CALIFORNIA (US) 2020-10-14 EP disclosed
EP-3104846-B1 MAO INHIBITORS AND THEIR CONJUGATES AS THERAPEUTICS FOR THE TREATMENT OF BRAIN CANCER UNIV SOUTHERN CALIFORNIA (US) 2020-10-14 EP disclosed
US-10561663-B2 MAO inhibitors and their conjugates as therapeutics for the treatment of brain cancer UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2020-02-18 US disclosed
US-20180360843-A1 MAO INHIBITORS AND THEIR CONJUGATES AS THERAPEUTICS FOR THE TREATMENT OF BRAIN CANCER UNIV SOUTHERN CALIFORNIA (US) 2018-12-20 US disclosed
EP-2736506-B1 MONOAMINE OXIDASE INHIBITORS AND METHODS FOR TREATMENT AND DIAGNOSIS OF PROSTATE CANCER UNIV SOUTHERN CALIFORNIA (US) 2018-09-05 EP disclosed
US-20180185303-A1 MONOAMINE OXIDASE INHIBITORS AND METHODS FOR TREATMENT AND DIAGNOSIS OF PROSTATE CANCER UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2018-07-05 US disclosed
US-20180185303-A1 MONOAMINE OXIDASE INHIBITORS AND METHODS FOR TREATMENT AND DIAGNOSIS OF PROSTATE CANCER UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2018-07-05 US disclosed
US-20180185303-A1 MONOAMINE OXIDASE INHIBITORS AND METHODS FOR TREATMENT AND DIAGNOSIS OF PROSTATE CANCER UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2018-07-05 US disclosed
US-9771625-B2 Monoamine oxidase inhibitors and methods for treatment and diagnosis of prostate cancer UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2017-09-26 US disclosed
US-9771625-B2 Monoamine oxidase inhibitors and methods for treatment and diagnosis of prostate cancer UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2017-09-26 US disclosed
US-20160339034-A9 MAO Inhibitors and Their Conjugates as Therapeutics For The Treatment of Brain Cancer UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2016-11-24 US disclosed
US-20160339034-A9 MAO Inhibitors and Their Conjugates as Therapeutics For The Treatment of Brain Cancer UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2016-11-24 US disclosed
WO-2015120206-A9 MAO INHIBITORS AND THEIR CONJUGATES AS THERAPEUTICS FOR THE TREATMENT OF BRAIN CANCER UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2015-12-17 WO disclosed
WO-2015120206-A1 MAO INHIBITORS AND THEIR CONJUGATES AS THERAPEUTICS FOR THE TREATMENT OF BRAIN CANCER UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2015-08-13 WO disclosed
US-20150209361-A1 MAO Inhibitors and Their Conjugates as Therapeutics For The Treatment of Brain Cancer UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2015-07-30 US disclosed
US-20150209361-A1 MAO Inhibitors and Their Conjugates as Therapeutics For The Treatment of Brain Cancer UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2015-07-30 US disclosed
EP-2736506-A2 MONOAMINE OXIDASE INHIBITORS AND METHODS FOR TREATMENT AND DIAGNOSIS OF PROSTATE CANCER University Of Southern California (US) 2014-06-04 EP disclosed
US-20130039854-A1 MONOAMINE OXIDASE INHIBITORS AND METHODS FOR TREATMENT AND DIAGNOSIS OF PROSTATE CANCER UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2013-02-14 US disclosed
US-20130039854-A1 MONOAMINE OXIDASE INHIBITORS AND METHODS FOR TREATMENT AND DIAGNOSIS OF PROSTATE CANCER UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2013-02-14 US disclosed
WO-2013016580-A2 MONOAMINE OXIDASE INHIBITORS AND METHODS FOR TREATMENT AND DIAGNOSIS OF PROSTATE CANCER UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2013-01-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180360843-A1 MAO INHIBITORS AND THEIR CONJUGATES AS THERAPEUTICS FOR THE TREATMENT OF BRAIN CANCER MAOA, MAOB, COMT TP53 1706/4885MAPK1 2652/4885L3MBTL1 3733/4885
US-20180185303-A1 MONOAMINE OXIDASE INHIBITORS AND METHODS FOR TREATMENT AND DIAGNOSIS OF PROSTATE CANCER MAOA, COMT, MAOB TP53 2599/4885MAPK1 4288/4885L3MBTL1 1531/4885
US-20130039854-A1 MONOAMINE OXIDASE INHIBITORS AND METHODS FOR TREATMENT AND DIAGNOSIS OF PROSTATE CANCER MAOA, COMT, MAOB TP53 2599/4885MAPK1 4288/4885L3MBTL1 1531/4885
US-10561663-B2 MAO inhibitors and their conjugates as therapeutics for the treatment of brain cancer MAOA, MAOB, COMT TP53 1706/4885MAPK1 2652/4885L3MBTL1 3733/4885
US-20150209361-A1 MAO Inhibitors and Their Conjugates as Therapeutics For The Treatment of Brain Cancer MAOA, MAOB, COMT TP53 1706/4885MAPK1 2652/4885L3MBTL1 3733/4885
US-20160339034-A9 MAO Inhibitors and Their Conjugates as Therapeutics For The Treatment of Brain Cancer MAOA, MAOB, COMT TP53 1706/4885MAPK1 2652/4885L3MBTL1 3733/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.