Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 4/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.50 |
| ▸ | MLNR | O43193 | 1/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11137640 | 0.92 | LMNA (0.58) | LMNAMAPK1HPGDALDH1A1MAPT | |
| SCHEMBL97551 | 0.85 | MAPK1 (0.70) | LMNAMAPK1HPGDALDH1A1MAPT | |
| SCHEMBL30530511 | 0.85 | MAPK1 (0.70) | LMNAMAPK1HPGDALDH1A1MAPT | |
| SCHEMBL97994 | 0.84 | LMNA (0.62) | LMNAMAPK1HPGDALDH1A1MAPT | |
| SCHEMBL30947438 | 0.83 | LMNA (0.78) | LMNAMAPK1HPGDALDH1A1MAPT | |
| SCHEMBL27780501 | 0.81 | MAPK1 (0.61) | LMNAMAPK1HPGDALDH1A1MAPT | |
| SCHEMBL13240512 | 0.81 | LMNA (0.58) | LMNAMAPK1HPGDALDH1A1MAPT | |
| SCHEMBL133515 | 0.81 | LMNA (0.58) | LMNAMAPK1HPGDALDH1A1MAPT | |
| SCHEMBL11514674 | 0.81 | LMNA (0.58) | LMNAMAPK1HPGDALDH1A1MAPT | |
| SCHEMBL11632907 | 0.80 | LMNA (0.69) | LMNAMAPK1HPGDALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8629134-B2 | Enantioselective synthesis of 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo[4,5,1-jk][1]-benzazepin-2[1H]-one and zilpaterol | INTERVET INTERNATIONAL B.V. (NL) | 2014-01-14 | — | — | US | disclosed |
| US-8362006-B2 | Processes for making zilpaterol and salts thereof | INTERVET INTERNATIONAL B.V. (NL) | 2013-01-29 | — | — | US | disclosed |
| US-20100173892-A1 | Enantioselective synthesis of 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo[4,5,1-JK][1]-benzazepin-2[1H]-one and zilpaterol | INTERVET INTERNATIONAL B.V. (NL) | 2010-07-08 | — | — | US | disclosed |
| US-20100121050-A1 | PROCESSES FOR MAKING ZILPATEROL AND SALTS THEREOF | INTERVET INTERNATIONAL B.V. (NL) | 2010-05-13 | — | — | US | disclosed |
| EP-1608627-B1 | BICYCLIC ANILIDE SPIROHYDANTOIN CGRP RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2008-05-07 | — | — | EP | disclosed |
| US-7202251-B2 | Bicyclic anilide spirohydantoin CGRP receptor antagonists | MERCK & CO., INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-7202251-B2 | Bicyclic anilide spirohydantoin CGRP receptor antagonists | MERCK & CO., INC. (US) | 2007-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100121050-A1 | PROCESSES FOR MAKING ZILPATEROL AND SALTS THEREOF | SLC39A11, SLC39A3, ZFR | LMNA 1307/4885MAPK1 2812/4885HPGD 1783/4885 |
| US-20100173892-A1 | Enantioselective synthesis of 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo[4,5,1-JK][1]-benzazepin-2[1H]-one and zilpaterol | KHK, KCNJ2, GRIK1 | LMNA 4256/4885MAPK1 897/4885HPGD 1084/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.