Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.55 |
| ▸ | ALB | P02768 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.55 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.55 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.48 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.48 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.48 |
| ▸ | POLG | P54098 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NT5E | P21589 | 1/20 | 0.36 |
| ▸ | POLA1 | P09884 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13389626 | 1.00 | PDE3A (0.55) | PDE3ALMNACACNA1FALBMAPT | |
| SCHEMBL13408030 | 1.00 | PDE3A (0.55) | PDE3ALMNACACNA1FALBMAPT | |
| SCHEMBL13389755 | 1.00 | PDE3A (0.55) | PDE3ALMNACACNA1FALBMAPT | |
| SCHEMBL21099827 | 0.87 | LMNA (0.56) | PDE3ALMNACACNA1FALBMAPT | |
| SCHEMBL14664275 | 0.84 | PDE3A (0.53) | PDE3ALMNACACNA1FALBMAPT | |
| SCHEMBL13389629 | 0.84 | PDE3A (0.53) | PDE3ALMNACACNA1FALBMAPT | |
| SCHEMBL13389746 | 0.84 | PDE3A (0.53) | PDE3ALMNACACNA1FALBMAPT | |
| SCHEMBL9856192 | 0.83 | LMNA (0.57) | PDE3ALMNACACNA1FALBMAPT | |
| SCHEMBL6304425 | 0.83 | PDE3A (0.57) | PDE3ALMNACACNA1FALBMAPT | |
| SCHEMBL6758002 | 0.83 | PDE3A (0.57) | PDE3ALMNACACNA1FALBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8361988-B2 | Nucleoside and nucleotide analogues with quaternary carbon centers and methods of use | INSTITUT DE RECHERCHES CLINIQUES DE MONTREAL (CA) | 2013-01-29 | — | — | US | disclosed |