Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.55 |
| ▸ | ALB | P02768 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.55 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.55 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.48 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.48 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.48 |
| ▸ | POLG | P54098 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NT5E | P21589 | 1/20 | 0.36 |
| ▸ | POLA1 | P09884 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13389626 | 1.00 | PDE3A (0.55) | PDE3ALMNACACNA1FALBMAPT | |
| SCHEMBL13389755 | 1.00 | PDE3A (0.55) | PDE3ALMNACACNA1FALBMAPT | |
| SCHEMBL14664274 | 1.00 | PDE3A (0.55) | PDE3ALMNACACNA1FALBMAPT | |
| SCHEMBL21099827 | 0.87 | LMNA (0.56) | PDE3ALMNACACNA1FALBMAPT | |
| SCHEMBL14664275 | 0.84 | PDE3A (0.53) | PDE3ALMNACACNA1FALBMAPT | |
| SCHEMBL13389629 | 0.84 | PDE3A (0.53) | PDE3ALMNACACNA1FALBMAPT | |
| SCHEMBL13389746 | 0.84 | PDE3A (0.53) | PDE3ALMNACACNA1FALBMAPT | |
| SCHEMBL9856192 | 0.83 | LMNA (0.57) | PDE3ALMNACACNA1FALBMAPT | |
| SCHEMBL6304425 | 0.83 | PDE3A (0.57) | PDE3ALMNACACNA1FALBMAPT | |
| SCHEMBL6758002 | 0.83 | PDE3A (0.57) | PDE3ALMNACACNA1FALBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8361988-B2 | Nucleoside and nucleotide analogues with quaternary carbon centers and methods of use | INSTITUT DE RECHERCHES CLINIQUES DE MONTREAL (CA) | 2013-01-29 | — | — | US | disclosed |
| US-20100093737-A1 | Nucleoside and Nucleotide Analogues with Quaternary Carbon Centers and Methods of Use | INSTITUT DE RECHERCHES CLINIQUES DE MONTREAL (CA) | 2010-04-15 | — | — | US | disclosed |
| WO-2008087558-A2 | NUCLEOSIDE AND NUCLEOTIDE ANALOGUES WITH QUATERNARY CARBON CENTERS AND METHODS OF USE | INSTITUT DE RECHERCHES CLINIQUES DE MONTREAL (CA) | 2008-07-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093737-A1 | Nucleoside and Nucleotide Analogues with Quaternary Carbon Centers and Methods of Use | NUDT1, NT5C3B, NTPCR | PDE3A 2044/4885LMNA 1497/4885CACNA1F 4106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.