Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.78 |
| ▸ | MAPT | P10636 | 4/20 | 0.78 |
| ▸ | MEN1 | O00255 | 3/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.78 |
| ▸ | BLM | P54132 | 2/20 | 0.78 |
| ▸ | GAA | P10253 | 1/20 | 0.78 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.78 |
| ▸ | TOP1 | P11387 | 3/20 | 0.71 |
| ▸ | TOP2A | P11388 | 3/20 | 0.71 |
| ▸ | HPGD | P15428 | 2/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.71 |
| ▸ | POLB | P06746 | 2/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.70 |
| ▸ | RAB9A | P51151 | 1/20 | 0.70 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.67 |
| ▸ | GLA | P06280 | 1/20 | 0.67 |
| ▸ | RECQL | P46063 | 1/20 | 0.67 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1552158 | 0.89 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2KDM4EMAPTMEN1 | |
| SCHEMBL18007159 | 0.88 | ALDH1A1 (0.78) | ALDH1A1SMN1; SMN2KDM4EMAPTMEN1 | |
| SCHEMBL14665620 | 0.88 | ALDH1A1 (0.78) | ALDH1A1SMN1; SMN2KDM4EMAPTMEN1 | |
| SCHEMBL16918643 | 0.84 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2KDM4EMAPTMEN1 | |
| SCHEMBL14091293 | 0.84 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2KDM4EMAPTMEN1 | |
| SCHEMBL16918646 | 0.84 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2KDM4EMAPTMEN1 | |
| SCHEMBL18595033 | 0.84 | SMN1; SMN2 (0.77) | ALDH1A1SMN1; SMN2KDM4EMAPTMEN1 | |
| SCHEMBL14399402 | 0.84 | ALDH1A1 (0.80) | ALDH1A1SMN1; SMN2KDM4EMAPTMEN1 | |
| Hoechst 33258 SCHEMBL29376223 | 0.83 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2KDM4EMAPTMEN1 | |
| SCHEMBL14665658 | 0.83 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2KDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9056887-B2 | Minor groove binder phosphoramidites and methods of use | ELITECH HOLDING B.V. (NL) | 2015-06-16 | — | — | US | disclosed |
| US-9056887-B2 | Minor groove binder phosphoramidites and methods of use | ELITECH HOLDING B.V. (NL) | 2015-06-16 | — | — | US | disclosed |
| US-20130030166-A1 | MINOR GROOVE BINDER PHOSPHORAMIDITES AND METHODS OF USE | ELITECH HOLDING B.V. | 2013-01-31 | — | — | US | disclosed |
| US-20130030166-A1 | MINOR GROOVE BINDER PHOSPHORAMIDITES AND METHODS OF USE | ELITECH HOLDING B.V. | 2013-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130030166-A1 | MINOR GROOVE BINDER PHOSPHORAMIDITES AND METHODS OF USE | PCNA, CD2BP2, BPGM | ALDH1A1 3831/4885SMN1; SMN2 3714/4885KDM4E 4345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.