Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 5/20 | 0.45 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | XPO1 | O14980 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | STK17B | O94768 | 1/20 | 0.32 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14670400 | 1.00 | NTRK1 (0.45) | NTRK1MAP4K1ALDH1A1L3MBTL1XPO1 | |
| SCHEMBL14670672 | 0.91 | NTRK1 (0.41) | NTRK1MAPK1 | |
| SCHEMBL14670588 | 0.89 | ALDH1A1 (0.43) | NTRK1MAP4K1ALDH1A1L3MBTL1XPO1 | |
| SCHEMBL14670525 | 0.87 | NTRK1 (0.44) | NTRK1MAP4K1MAPK1ROCK2RPS6KB1 | |
| SCHEMBL14670408 | 0.87 | NTRK1 (0.44) | NTRK1MAP4K1MAPK1ROCK2RPS6KB1 | |
| SCHEMBL14670594 | 0.87 | USP1 (0.42) | NTRK1MAP4K1ALDH1A1L3MBTL1XPO1 | |
| SCHEMBL14670569 | 0.86 | NTRK1 (0.58) | NTRK1MAP4K1ALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL4619629 | 0.86 | NTRK1 (0.58) | NTRK1MAP4K1ALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL14670670 | 0.81 | ALDH1A1 (0.39) | ALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL14662045 | 0.81 | EGFR (0.46) | NTRK1RPS6KB1CCNCCDK8EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140179664-A1 | Heterocyclyl Pyrimidine Analogues As JAK Inhibitors | CELLZOME LIMITED (GB) | 2014-06-26 | — | — | US | disclosed |
| US-20140179664-A1 | Heterocyclyl Pyrimidine Analogues As JAK Inhibitors | CELLZOME LIMITED (GB) | 2014-06-26 | — | — | US | disclosed |
| WO-2013014162-A1 | HETEROCYCLYL PYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2013-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179664-A1 | Heterocyclyl Pyrimidine Analogues As JAK Inhibitors | JAK1, JAK3, JAK2 | NTRK1 4690/4885MAP4K1 529/4885ALDH1A1 3464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.