Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.86 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.76 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.76 |
| ▸ | GAK | O14976 | 1/20 | 0.69 |
| ▸ | ABL1 | P00519 | 1/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.64 |
| ▸ | SRC | P12931 | 1/20 | 0.64 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.64 |
| ▸ | FLT3 | P36888 | 1/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.62 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.62 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.62 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.62 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.62 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15877091 | 0.92 | EGFR (1.00) | EGFRERBB2ERBB4GAKABL1 | |
| SCHEMBL15877090 | 0.92 | EGFR (1.00) | EGFRERBB2ERBB4GAKABL1 | |
| SCHEMBL20395184 | 0.88 | EGFR (0.85) | EGFRERBB2ERBB4GAKHDAC3 | |
| SCHEMBL14671648 | 0.87 | EGFR (0.76) | EGFRERBB2ERBB4ABL1PDGFRB | |
| SCHEMBL2525148 | 0.87 | EGFR (0.86) | EGFRERBB2ERBB4GAKHDAC2 | |
| SCHEMBL20412221 | 0.86 | EGFR (0.82) | EGFRERBB2ERBB4GAKHDAC3 | |
| SCHEMBL2251602 | 0.86 | EGFR (0.87) | EGFRERBB2ERBB4GAKHDAC3 | |
| SCHEMBL2544071 | 0.86 | EGFR (0.83) | EGFRERBB2ERBB4GAK | |
| SCHEMBL2508012 | 0.86 | EGFR (0.83) | EGFRERBB2ERBB4GAK | |
| SCHEMBL14671702 | 0.86 | EGFR (0.82) | EGFRERBB2ERBB4ABL1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013013640-A1 | QUINAZOLINE DERIVATIVE, PREPARATION METHOD THEREFOR, INTERMEDIATE, COMPOSITION AND APPLICATION THEREOF | 上海医药集团股份有限公司 (CN) | 2013-01-31 | — | — | WO | disclosed |