Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.76 |
| ▸ | ERBB2 | P04626 | 9/20 | 0.76 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.64 |
| ▸ | ABL1 | P00519 | 1/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.64 |
| ▸ | SRC | P12931 | 1/20 | 0.64 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.64 |
| ▸ | FLT3 | P36888 | 1/20 | 0.64 |
| ▸ | LCK | P06239 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15876851 | 0.92 | EGFR (0.90) | EGFRERBB2ERBB4ABL1PDGFRB | |
| SCHEMBL14671695 | 0.92 | EGFR (0.90) | EGFRERBB2ERBB4ABL1PDGFRB | |
| SCHEMBL14671703 | 0.92 | EGFR (0.90) | EGFRERBB2ERBB4ABL1PDGFRB | |
| SCHEMBL14671636 | 0.87 | EGFR (0.86) | EGFRERBB2ERBB4ABL1PDGFRB | |
| SCHEMBL15876897 | 0.87 | EGFR (1.00) | EGFRERBB2ERBB4ABL1PDGFRB | |
| SCHEMBL15876896 | 0.87 | EGFR (1.00) | EGFRERBB2ERBB4ABL1PDGFRB | |
| SCHEMBL15876895 | 0.87 | EGFR (1.00) | EGFRERBB2ERBB4ABL1PDGFRB | |
| SCHEMBL14671702 | 0.85 | EGFR (0.82) | EGFRERBB2ERBB4ABL1PDGFRB | |
| SCHEMBL2249350 | 0.84 | EGFR (0.64) | EGFRERBB2ERBB4LCK | |
| SCHEMBL17498511 | 0.83 | EGFR (0.75) | EGFRERBB2ERBB4SRCLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013013640-A1 | QUINAZOLINE DERIVATIVE, PREPARATION METHOD THEREFOR, INTERMEDIATE, COMPOSITION AND APPLICATION THEREOF | 上海医药集团股份有限公司 (CN) | 2013-01-31 | — | — | WO | disclosed |