Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.51 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CCR1 | P32246 | 2/20 | 0.47 |
| ▸ | CCR5 | P51681 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | LIPE | Q05469 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10291634 | 0.86 | CCR1 (0.60) | KCNH2CCR1DRD2 | |
| SCHEMBL4034093 | 0.82 | ALDH1A1 (0.57) | HRH3KCNH2SLC18A3ADAMTS5ALDH1A1 | |
| SCHEMBL24340329 | 0.80 | ADAMTS5 (0.61) | HRH3KCNH2SLC18A3ADAMTS5CCR1 | |
| SCHEMBL4198757 | 0.80 | NAMPT (0.65) | HRH3KCNH2SLC18A3ADAMTS5ALDH1A1 | |
| SCHEMBL15840473 | 0.79 | ADAMTS5 (0.58) | HRH3KCNH2ADAMTS5ALDH1A1POLB | |
| SCHEMBL28154378 | 0.79 | ACACB (0.46) | KCNH2ADAMTS5KDM4ECYP2C9CYP2C19 | |
| SCHEMBL6245254 | 0.78 | NAMPT (0.64) | HRH3KCNH2SLC18A3ADAMTS5ALDH1A1 | |
| SCHEMBL19703077 | 0.78 | ADAMTS5 (0.57) | HRH3KCNH2ADAMTS5ALDH1A1POLB | |
| SCHEMBL17787758 | 0.77 | ALDH1A1 (0.59) | HRH3KCNH2SLC18A3ADAMTS5ALDH1A1 | |
| SCHEMBL8904765 | 0.76 | ALDH1A1 (0.57) | HRH3KCNH2SLC18A3ADAMTS5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013013273-A1 | MODULATORS OF PROTEASE ACTIVATED RECEPTORS | THE UNIVERSITY OF QUEENSLAND (AU) | 2013-01-31 | — | — | WO | disclosed |