Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Homatropine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 6/20 | 0.92 |
| ▸ | CHRM1 known ✓ | P11229 | 6/20 | 0.92 |
| ▸ | CHRM3 known ✓ | P20309 | 6/20 | 0.92 |
| ▸ | CHRM5 known ✓ | P08912 | 5/20 | 0.92 |
| ▸ | CHRM4 known ✓ | P08173 | 4/20 | 0.92 |
| ▸ | HRH2 known ✓ | P25021 | 1/20 | 0.54 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.95 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.95 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.95 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.95 |
| ▸ | BLM | P54132 | 2/20 | 0.92 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.92 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.92 |
| ▸ | HTR2C | P28335 | 3/20 | 0.67 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.67 |
| ▸ | HRH1 | P35367 | 2/20 | 0.67 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Homatropine SCHEMBL658437 | 1.00 | LMNA (0.95) | LMNACYP2D6CYP2C9HSD17B10CHRM2 | |
| Homatropine SCHEMBL23970 | 0.97 | LMNA (1.00) | LMNACYP2D6CYP2C9HSD17B10CHRM2 | |
| Homatropine SCHEMBL9653008 | 0.97 | LMNA (1.00) | LMNACYP2D6CYP2C9HSD17B10CHRM2 | |
| Homatropine SCHEMBL15275620 | 0.97 | LMNA (1.00) | LMNACYP2D6CYP2C9HSD17B10CHRM2 | |
| Homatropine SCHEMBL23969 | 0.97 | LMNA (1.00) | LMNACYP2D6CYP2C9HSD17B10CHRM2 | |
| Homatropine SCHEMBL23468168 | 0.97 | LMNA (1.00) | LMNACYP2D6CYP2C9HSD17B10CHRM2 | |
| Homatropine SCHEMBL41951 | 0.96 | CHRM2 (1.00) | LMNACYP2D6CYP2C9HSD17B10CHRM2 | |
| Homatropine SCHEMBL220965 | 0.96 | LMNA (0.97) | LMNACYP2D6CYP2C9HSD17B10CHRM2 | |
| Homatropine SCHEMBL41950 | 0.96 | CHRM2 (1.00) | LMNACYP2D6CYP2C9HSD17B10CHRM2 | |
| Homatropine SCHEMBL220964 | 0.96 | LMNA (0.97) | LMNACYP2D6CYP2C9HSD17B10CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114414679-B | Method for detecting belladonna alkaloid in animal tissues | 吉林省农业科学院 | 2024-05-07 | — | — | CN | disclosed |
| CN-114414679-A | Method for detecting belladonna alkaloid in animal tissue | 吉林省农业科学院 | 2022-04-29 | — | — | CN | disclosed |
| EP-2554184-B1 | PREVENTIVE AND/OR REMEDY FOR HAND AND FOOT SYNDROME | ONO PHARMACEUTICAL CO (JP) | 2016-10-26 | — | — | EP | disclosed |
| CN-104313603-B | Stud welding unit sanitising agent | LIU XINXIA (CN) | 2016-04-27 | — | — | CN | disclosed |
| CN-104313603-A | Stud welding machine cleaning agent | LIU XINXIA | 2015-01-28 | — | — | CN | disclosed |
| US-8729056-B2 | Preventive and/or therapeutic agent of hand-foot syndrome | ONO PHARMACEUTICAL CO., LTD. (JP) | 2014-05-20 | — | — | US | disclosed |
| US-20130045956-A1 | PREVENTIVE AND/OR THERAPEUTIC AGENT OF HAND-FOOT SYNDROME | ONO PHARMACEUTICAL CO., LTD. (JP) | 2013-02-21 | — | — | US | disclosed |
| EP-2554184-A1 | PREVENTIVE AND/OR REMEDY FOR HAND AND FOOT SYNDROME | ONO Pharmaceutical Co., Ltd. (JP) | 2013-02-06 | — | — | EP | disclosed |