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Cm-4307

Cm-4307

SCHEMBL14673524

Cc1ccc(S(=O)(=O)O)cc1.[2H]C([2H])([2H])NC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1

nearest known ligand 0.90

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

BRAFFLT1FLT3FLT4KDRKITPDGFRBRAF1RET

The experimentally established mechanism targets of Cm-4307. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDR known ✓ P35968 5/20 0.90
▸ RAF1 known ✓ P04049 12/20 0.72
▸ PDGFRB known ✓ P09619 4/20 0.72
▸ BRAF known ✓ P15056 4/20 0.72
▸ RET known ✓ P07949 3/20 0.72
▸ KIT known ✓ P10721 2/20 0.72
▸ FLT1 known ✓ P17948 2/20 0.72
▸ FLT4 known ✓ P35916 2/20 0.72
▸ FLT3 known ✓ P36888 2/20 0.72
▸ AURKB Q96GD4 2/20 0.90
▸ NTSR1 P30989 1/20 0.90
▸ MC4R P32245 1/20 0.90
▸ PAX8 Q06710 1/20 0.90
▸ RIPK2 O43353 2/20 0.72
▸ ABCB11 O95342 2/20 0.72
▸ ABL1 P00519 2/20 0.72
▸ HTR1A P08908 2/20 0.72
▸ ADORA3 P0DMS8 2/20 0.72
▸ FGFR1 P11362 2/20 0.72
▸ PDGFRA P16234 2/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Sorafenib SCHEMBL18496409 0.95 KDR (1.00) KDRAURKBNTSR1MC4RPAX8
Sorafenib SCHEMBL162935 0.95 KDR (1.00) KDRAURKBNTSR1MC4RPAX8
Sorafenib SCHEMBL15939735 0.95 KDR (1.00) KDRAURKBNTSR1MC4RPAX8
Sorafenib SCHEMBL29919725 0.95 KDR (1.00) KDRAURKBNTSR1MC4RPAX8
Sorafenib SCHEMBL28204502 0.94 KDR (0.98) KDRAURKBNTSR1MC4RPAX8
Sorafenib SCHEMBL3660939 0.94 KDR (0.98) KDRAURKBNTSR1MC4RPAX8
Sorafenib SCHEMBL16051185 0.92 KDR (0.94) KDRAURKBNTSR1MC4RPAX8
Sorafenib SCHEMBL3664023 0.92 KDR (0.94) KDRAURKBNTSR1MC4RPAX8
Cm-4307 SCHEMBL14480690 0.91 RAF1 (0.88) KDRAURKBNTSR1MC4RPAX8
Cm-4307 SCHEMBL30172564 0.91 RAF1 (0.88) KDRAURKBNTSR1MC4RPAX8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130035492-A1 METHOD AND PROCESS FOR PREPARATION AND PRODUCTION OF DEUTERATED OMEGA-DIPHENYLUREA SUZHOU ZELGEN BIOPHARMACEUTICAL CO., LTD. 2013-02-07 — — US claimed
US-8669369-B2 Method and process for preparation and production of deuterated Ω-diphenylurea SUZHOU ZELGEN BIOPHARMACEUTICAL CO., LTD. (CN) 2014-03-11 — — US disclosed
US-20130035492-A1 METHOD AND PROCESS FOR PREPARATION AND PRODUCTION OF DEUTERATED OMEGA-DIPHENYLUREA SUZHOU ZELGEN BIOPHARMACEUTICAL CO., LTD. 2013-02-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130035492-A1 METHOD AND PROCESS FOR PREPARATION AND PRODUCTION OF DEUTERATED OMEGA-DIPHENYLUREA PNLIP, PDXK, PNP KDR 3367/4885RAF1 1962/4885PDGFRB 340/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.