Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | CA7 | P43166 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | USP2 | O75604 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13102979 | 0.98 | HPGD (0.71) | HPGDKMT2ACA1CA2CA7 | |
| SCHEMBL18617528 | 0.88 | HPGD (0.58) | HPGDKMT2ACA1CA2CA7 | |
| SCHEMBL12993899 | 0.87 | KMT2A (0.64) | HPGDKMT2ACA1CA2CA7 | |
| SCHEMBL9615508 | 0.86 | L3MBTL1 (0.62) | HPGDKMT2ACA1CA2CA7 | |
| SCHEMBL18659987 | 0.86 | CA1 (0.60) | HPGDKMT2ACA1CA2CA7 | |
| SCHEMBL14679139 | 0.86 | KMT2A (0.67) | HPGDKMT2ACA1CA2CA7 | |
| SCHEMBL6192050 | 0.86 | KMT2A (0.78) | KMT2ACA1CA2CA7CA9 | |
| SCHEMBL10195736 | 0.85 | HTT (0.76) | HPGDKMT2ACA1CA2CA7 | |
| SCHEMBL14679161 | 0.85 | HPGD (0.59) | HPGDKMT2ACA1CA2CA7 | |
| SCHEMBL14679394 | 0.84 | KMT2A (0.56) | HPGDKMT2AHTTMEN1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367668-B2 | Pyridazinone derivatives | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2013-02-05 | — | — | US | disclosed |
| US-8367668-B2 | Pyridazinone derivatives | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2013-02-05 | — | — | US | disclosed |