Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.78 |
| ▸ | HTT | P42858 | 2/20 | 0.73 |
| ▸ | USP2 | O75604 | 1/20 | 0.73 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
| ▸ | CA7 | P43166 | 1/20 | 0.59 |
| ▸ | CA9 | Q16790 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.56 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.56 |
| ▸ | RORC | P51449 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3844592 | 0.92 | HTT (0.79) | KMT2AHTTUSP2MEN1GAA | |
| SCHEMBL4818022 | 0.86 | CA1 (0.76) | KMT2AHTTUSP2MEN1GAA | |
| SCHEMBL14679142 | 0.86 | HPGD (0.69) | KMT2AHTTUSP2MEN1NPSR1 | |
| SCHEMBL12359542 | 0.84 | HTT (0.70) | KMT2AHTTUSP2MEN1GAA | |
| SCHEMBL9615508 | 0.84 | L3MBTL1 (0.62) | KMT2AHTTUSP2MEN1GAA | |
| SCHEMBL3114053 | 0.84 | KMT2A (0.58) | KMT2AHTTUSP2MEN1GAA | |
| SCHEMBL6524983 | 0.84 | HTT (0.69) | KMT2AHTTUSP2MEN1GAA | |
| SCHEMBL13102979 | 0.84 | HPGD (0.71) | KMT2AHTTUSP2MEN1NPSR1 | |
| SCHEMBL15307634 | 0.83 | HTT (0.68) | KMT2AHTTUSP2MEN1GAA | |
| Hydrochloric Acid SCHEMBL3838598 | 0.83 | HTT (0.68) | KMT2AHTTUSP2MEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-A4 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2005-03-30 | — | — | EP | disclosed |
| EP-1465631-A2 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI Pharmaceuticals, Inc. (US) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003053366-A2 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARMACEUTICALS, INC. (US) | 2003-07-03 | — | — | WO | disclosed |