Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.64 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.64 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.64 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.64 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.64 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.64 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | TERT | O14746 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL259122 | 0.85 | HDAC3 (0.61) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL13102519 | 0.84 | HPGD (0.62) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL3651019 | 0.83 | HDAC3 (0.62) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL14679379 | 0.82 | HDAC3 (0.69) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL13994594 | 0.82 | HDAC3 (0.69) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL10122853 | 0.82 | ICMT (0.60) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL2014002 | 0.81 | MEN1 (0.72) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL17376724 | 0.81 | HDAC3 (0.68) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL259380 | 0.81 | HDAC3 (0.68) | HDAC3HDAC1HDAC2HDAC10HDAC11 | |
| SCHEMBL22868061 | 0.81 | HDAC3 (0.68) | HDAC3HDAC1HDAC2HDAC10HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367668-B2 | Pyridazinone derivatives | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2013-02-05 | — | — | US | disclosed |