Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 7/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | ACR | P10323 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10102028 | 0.89 | HDAC3 (0.38) | MAPTLMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10107545 | 0.85 | TLR8 (0.34) | CYP3A4CYP2D6NPC1TLR7 | |
| SCHEMBL10107617 | 0.84 | FAAH (0.39) | FAAHMAPTTSHRLMNACYP1A2 | |
| SCHEMBL10107486 | 0.84 | LMNA (0.41) | FAAHMAPTTSHRLMNACYP1A2 | |
| SCHEMBL10107487 | 0.80 | MAPT (0.39) | FAAHMAPTTSHRLMNACYP1A2 | |
| SCHEMBL16015533 | 0.78 | LMNA (0.36) | FAAHMAPTTSHRLMNACYP1A2 | |
| SCHEMBL10107544 | 0.78 | F2 (0.34) | FAAHMAPTTSHRLMNACYP1A2 | |
| SCHEMBL10107473 | 0.76 | LMNA (0.43) | FAAHMAPTTSHRLMNACYP1A2 | |
| SCHEMBL14679438 | 0.75 | MCHR1 (0.37) | FAAHMAPTTSHRLMNACYP1A2 | |
| SCHEMBL10107474 | 0.73 | LMNA (0.44) | FAAHMAPTTSHRLMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8828988-B2 | 8-AZA tetracycline compounds | TETRAPHASE PHARMACEUTICALS, INC. (US) | 2014-09-09 | — | — | US | disclosed |
| EP-2427190-B1 | 8-AZA TETRACYCLINE COMPOUNDS | TETRAPHASE PHARMACEUTICALS INC (US) | 2013-09-18 | — | — | EP | disclosed |
| US-8367654-B2 | 8-AZA tetracycline compounds | TETRAPHASE PHARMACEUTICALS, INC. (US) | 2013-02-05 | — | — | US | disclosed |