Sugi Predict

Sugi Predict / Compounds / SCHEMBL1467964

SCHEMBL1467964

SCHEMBL1467964

O=C(Nc1c[nH]c2ncc(C(F)(F)F)c(Cl)c12)c1cccnc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ AAK1 Q2M2I8 9/20 0.56
▸ SCN5A Q14524 3/20 0.47
▸ SCN9A Q15858 3/20 0.47
▸ GAK O14976 1/20 0.47
▸ STK16 O75716 1/20 0.47
▸ PIM1 P11309 1/20 0.47
▸ AXL P30530 1/20 0.47
▸ NEK2 P51955 1/20 0.47
▸ STK3 Q13188 1/20 0.47
▸ STK11 Q15831 1/20 0.47
▸ BMP2K Q9NSY1 1/20 0.47
▸ TNIK Q9UKE5 1/20 0.47
▸ CLK1 P49759 1/20 0.46
▸ DYRK1A Q13627 1/20 0.46
▸ ALDH1A1 P00352 1/20 0.46
▸ KCNMA1 Q12791 1/20 0.46
▸ RXFP1 Q9HBX9 1/20 0.45
▸ MEN1 O00255 1/20 0.45
▸ TSHR P16473 1/20 0.45
▸ KMT2A Q03164 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1468676 0.84 MCL1 (0.46) ALDH1A1MEN1TSHRKMT2ASMN1; SMN2
SCHEMBL1469198 0.84 GRM4 (0.50) ALDH1A1MEN1KMT2ASMN1; SMN2NPC1
SCHEMBL1467820 0.81 AAK1 (0.57) AAK1GAKSTK16PIM1AXL
SCHEMBL1468749 0.79 AAK1 (0.57) AAK1GAKSTK16PIM1AXL
SCHEMBL1469033 0.79 AAK1 (0.59) AAK1GAKSTK16PIM1AXL
SCHEMBL1468059 0.76 PIM2 (0.46) AAK1PIM1
SCHEMBL1468054 0.76 PIM2 (0.46) AAK1PIM1
Hydrochloric Acid SCHEMBL1468771 0.75 PIM2 (0.46) AAK1PIM1
Hydrochloric Acid SCHEMBL1468769 0.75 PIM2 (0.46) AAK1PIM1
SCHEMBL5694521 0.74 ALDH1A1 (0.75) SCN5ASCN9AALDH1A1RXFP1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109942575-A Pyrrolopyridine as kinase inhibitor 阵列生物制药公司 2019-06-28 — — CN disclosed
CN-104926810-B Pyrrolopyridine as kinase inhibitor 阵列生物制药公司 2019-02-19 — — CN disclosed
US-9969727-B2 Pyrrolopyridines as kinase inhibitors ARRAY BIOPHARMA INC. (US) 2018-05-15 — — US disclosed
US-20160368916-A1 PYRROLOPYRIDINES AS KINASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2016-12-22 — — US disclosed
US-9365568-B2 Pyrrolopyridines as kinase inhibitors ARRAY BIOPHARMA INC. (US) 2016-06-14 — — US disclosed
EP-2990407-A1 PYRROLOPYRIDINES AS KINASE INHIBITORS Array Biopharma, Inc. (US) 2016-03-02 — — EP disclosed
US-20150322061-A1 PYRROLOPYRIDINES AS KINASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2015-11-12 — — US disclosed
EP-2307409-B1 PYRROLOPYRIDINES AS KINASE INHIBITORS ARRAY BIOPHARMA INC (US) 2015-08-12 — — EP disclosed
US-8981085-B2 Pyrrolopyridines as kinase inhibitors ARRAY BIOPHARMA INC. (US) 2015-03-17 — — US disclosed
US-20140243520-A1 PYRROLOPYRIDINES AS KINASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2014-08-28 — — US disclosed
US-8758830-B2 Pyrrolopyridines as kinase inhibitors ARRAY BIOPHARMA, INC. (US) 2014-06-24 — — US disclosed
US-20140100369-A1 PYRROLOPYRIDINES AS KINASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2014-04-10 — — US disclosed
US-8545897-B2 Pyrrolopyridines as kinase inhibitors ARRAY BIOPHARMA INC. (US) 2013-10-01 — — US disclosed
US-20130045286-A1 PYRROLOPYRIDINES AS KINASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2013-02-21 — — US disclosed
US-8178131-B2 Pyrrolopyridines as kinase inhibitors ARRAY BIOPHARMA INC. (US) 2012-05-15 — — US disclosed
CN-102089307-A Pyrrolopyridines as kinase inhibitors ARRAY BIOPHARMA INC 2011-06-08 — — CN disclosed
EP-2307409-A1 PYRROLOPYRIDINES AS KINASE INHIBITORS Array Biopharma, Inc. (US) 2011-04-13 — — EP disclosed
US-20110070317-A1 PYRROLOPYRIDINES AS KINASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2011-03-24 — — US disclosed
WO-2009140320-A1 PYRROLOPYRIDINES AS KINASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2009-11-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140243520-A1 PYRROLOPYRIDINES AS KINASE INHIBITORS CHEK2, CHEK1, CDKN1A AAK1 438/4885SCN5A 3022/4885SCN9A 3660/4885
US-20160368916-A1 PYRROLOPYRIDINES AS KINASE INHIBITORS CHEK2, CHEK1, CDKN1A AAK1 438/4885SCN5A 3022/4885SCN9A 3660/4885
US-20140100369-A1 PYRROLOPYRIDINES AS KINASE INHIBITORS CHEK2, CHEK1, CDKN1A AAK1 438/4885SCN5A 3022/4885SCN9A 3660/4885
US-20110070317-A1 PYRROLOPYRIDINES AS KINASE INHIBITORS CHEK2, CHEK1, BUB1B AAK1 453/4885SCN5A 2979/4885SCN9A 3654/4885
US-20150322061-A1 PYRROLOPYRIDINES AS KINASE INHIBITORS CHEK2, CHEK1, CDKN1A AAK1 438/4885SCN5A 3022/4885SCN9A 3660/4885
US-20130045286-A1 PYRROLOPYRIDINES AS KINASE INHIBITORS CHEK2, CHEK1, CDKN1A AAK1 438/4885SCN5A 3022/4885SCN9A 3660/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.