Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 11/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12618996 | 0.79 | KDM4E (0.39) | AKT1AKT2ALDH1A1KDM4EGLA | |
| SCHEMBL14685293 | 0.78 | CYP11B1 (0.49) | PDE10AMCHR1ALDH1A1LMNATSHR | |
| SCHEMBL14685287 | 0.78 | MCHR1 (0.43) | PDE10AMCHR1ALDH1A1LMNATSHR | |
| SCHEMBL14685307 | 0.75 | PDE10A (0.51) | PDE10AMCHR1 | |
| SCHEMBL14685178 | 0.72 | ALDH1A1 (0.47) | PDE10AMCHR1ALDH1A1KDM4EGLA | |
| SCHEMBL14685158 | 0.68 | GAA (0.40) | MCHR1ALDH1A1KDM4EGAALMNA | |
| SCHEMBL22146347 | 0.68 | KDM4E (0.35) | PDE10AAKT1AKT2ALDH1A1KDM4E | |
| SCHEMBL24424306 | 0.67 | TNKS (0.41) | AKT1AKT2ALDH1A1KDM4EGLA | |
| SCHEMBL14685216 | 0.67 | ALDH1A1 (0.45) | PDE10AMCHR1ALDH1A1KDM4EGLA | |
| SCHEMBL14685221 | 0.67 | ADORA1 (0.47) | PDE10AMCHR1ALDH1A1KDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2740730-B1 | DIBENZOOXEPIN DERIVATIVE | KYOWA HAKKO KIRIN CO LTD (JP) | 2016-11-16 | — | — | EP | disclosed |
| US-8969345-B2 | Dibenzooxepin derivative | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2015-03-03 | — | — | US | disclosed |
| US-8969345-B2 | Dibenzooxepin derivative | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2015-03-03 | — | — | US | disclosed |
| EP-2740730-A1 | DIBENZOOXEPIN DERIVATIVE | Kyowa Hakko Kirin Co., Ltd. (JP) | 2014-06-11 | — | — | EP | disclosed |
| WO-2013018899-A1 | DIBENZOOXEPIN DERIVATIVE | 協和発酵キリン株式会社 (JP) | 2013-02-07 | — | — | WO | disclosed |