Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.37 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.37 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14686114 | 1.00 | DRD2 (0.48) | DRD2HTR1AHTR2ADRD3CYP1A2 | |
| Hydrochloric Acid SCHEMBL2514759 | 0.98 | DRD2 (0.47) | DRD2HTR1AHTR2ADRD3CYP1A2 | |
| Hydrochloric Acid SCHEMBL2514757 | 0.98 | DRD2 (0.47) | DRD2HTR1AHTR2ADRD3CYP1A2 | |
| SCHEMBL8587237 | 0.89 | CYP1A2 (0.50) | DRD2DRD3CYP1A2CHRM5ADRA2C | |
| SCHEMBL10153844 | 0.86 | CYP1A2 (0.54) | CYP1A2CHRM5ADRA2CHRH3L3MBTL1 | |
| SCHEMBL13415665 | 0.83 | DRD2 (0.49) | DRD2HTR1AHTR2ADRD3GNAI3 | |
| SCHEMBL13391216 | 0.83 | DRD2 (0.49) | DRD2HTR1AHTR2ADRD3GNAI3 | |
| SCHEMBL11921122 | 0.82 | DRD2 (0.48) | DRD2HTR1AHTR2ADRD3GNAI3 | |
| SCHEMBL10949210 | 0.81 | CHRM5 (0.54) | CYP1A2CHRM5ADRA2CHRH3 | |
| SCHEMBL12945 | 0.79 | CHRM5 (0.58) | CYP1A2CHRM5ADRA2CHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074083-B1 | NEW SULFONAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS | RICHTER GEDEON NYRT (HU) | 2013-06-19 | — | — | EP | disclosed |
| EP-2057116-B1 | NEW PHENYLSULFAMOYL BENZAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS | RICHTER GEDEON NYRT (HU) | 2013-02-13 | — | — | EP | disclosed |