Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GALR2 | O43603 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAT2A | P31153 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | BMI1 | P35226 | 1/20 | 0.36 |
| ▸ | GALR1 | P47211 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5458624 | 0.89 | MAPKAPK2 (0.41) | RAB9AGAAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL14686295 | 0.87 | MAPT (0.38) | GAAMAPTSMN1; SMN2NPSR1KDM4E | |
| SCHEMBL22158559 | 0.85 | MAPKAPK2 (0.39) | RAB9AMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL3023055 | 0.84 | MAPK8 (0.38) | RAB9AGAAMAPTPOLBSMN1; SMN2 | |
| SCHEMBL14686135 | 0.84 | IGF1R (0.35) | CCNE1CDK2FLT3 | |
| SCHEMBL14686146 | 0.79 | MAPK1 (0.38) | RAB9AMAPTMEN1KMT2AMAT2A | |
| SCHEMBL14686217 | 0.79 | EGFR (0.38) | RAB9AMAPTFLT3 | |
| SCHEMBL14686138 | 0.78 | GALR2 (0.35) | RAB9AGAAMAPTPOLBSMN1; SMN2 | |
| SCHEMBL14686164 | 0.76 | PIM1 (0.41) | GAAMAPTMEN1KMT2ALMNA | |
| SCHEMBL14686229 | 0.75 | EGFR (0.33) | MAPTMAPK8MAPK9MAPK10MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928879-B1 | FUSED HETEROCYCLIC COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2013-02-13 | — | — | EP | disclosed |