Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR2 | O43603 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3023450 | 0.85 | RAB9A (0.33) | GALR2LMNAGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL14686229 | 0.80 | EGFR (0.33) | MAPT | |
| SCHEMBL14686148 | 0.78 | RAB9A (0.40) | GALR2LMNAGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL3025242 | 0.78 | DPP4 (0.35) | LMNASMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL14686135 | 0.77 | IGF1R (0.35) | — | |
| SCHEMBL3019914 | 0.76 | KARS1 (0.41) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL3019754 | 0.76 | RIPK2 (0.35) | SMN1; SMN2ALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL3024873 | 0.76 | LYN (0.39) | GAASMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL3019257 | 0.76 | LYN (0.39) | GAASMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL3022058 | 0.76 | KARS1 (0.41) | ALDH1A1NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928879-B1 | FUSED HETEROCYCLIC COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2013-02-13 | — | — | EP | disclosed |