Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM6B | O15054 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10490374 | 0.82 | HSD17B10 (0.50) | HSD17B10BACE1KDM4EHPGDTSHR | |
| SCHEMBL17468739 | 0.81 | HSD17B10 (0.49) | HSD17B10BACE1KDM4EHPGDTSHR | |
| SCHEMBL6953610 | 0.81 | HSD17B10 (0.49) | HSD17B10BACE1KDM4EHPGDTSHR | |
| SCHEMBL12859084 | 0.78 | HSD17B10 (0.53) | HSD17B10BACE1KDM4EHPGDTSHR | |
| SCHEMBL4571036 | 0.76 | HSD17B10 (0.71) | HSD17B10BACE1KDM4EHPGDTSHR | |
| SCHEMBL30464743 | 0.76 | HSD17B10 (0.71) | HSD17B10BACE1KDM4EHPGDTSHR | |
| SCHEMBL8935356 | 0.76 | HSD17B10 (0.44) | HSD17B10BACE1KDM4EHPGDALDH1A1 | |
| SCHEMBL5793136 | 0.74 | HSD17B10 (0.42) | HSD17B10BACE1KDM4EHPGDTSHR | |
| SCHEMBL28864994 | 0.74 | HSD17B10 (0.49) | HSD17B10BACE1KDM4EHPGDTSHR | |
| SCHEMBL17463622 | 0.72 | BACE1 (0.42) | HSD17B10BACE1KDM4EHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227233-B1 | IDO INHIBITORS | NEWLINK GENETICS (US) | 2013-02-13 | — | — | EP | claimed |