Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 18/20 | 0.49 |
| ▸ | RET | P07949 | 2/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | FRK | P42685 | 2/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.45 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.45 |
| ▸ | BCR | P11274 | 1/20 | 0.45 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.45 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.45 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.45 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.45 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.45 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.45 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.45 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL60193 | 0.92 | TYRO3 (0.46) | TYRO3RETFGFR1FLT3FRK | |
| SCHEMBL5036616 | 0.91 | RET (0.52) | TYRO3RETFGFR1FLT3FRK | |
| SCHEMBL59474 | 0.91 | RET (0.45) | TYRO3RETFGFR1FLT3FRK | |
| SCHEMBL59179 | 0.90 | RET (0.47) | TYRO3RETFGFR1FLT3FRK | |
| SCHEMBL58990 | 0.90 | TYRO3 (0.49) | TYRO3RETFGFR1FLT3FRK | |
| SCHEMBL28776688 | 0.90 | TYRO3 (0.54) | TYRO3RETFGFR1FLT3FRK | |
| SCHEMBL58989 | 0.89 | RET (0.43) | TYRO3RETFGFR1FLT3FRK | |
| SCHEMBL59311 | 0.89 | TYRO3 (0.52) | TYRO3RETFGFR1FLT3FRK | |
| SCHEMBL27768250 | 0.88 | TYRO3 (0.46) | TYRO3RETFGFR1FLT3FRK | |
| SCHEMBL5031566 | 0.87 | FGFR1 (0.51) | TYRO3RETFGFR1FLT3FRK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957485-B1 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER HEALTHCARE LLC (US) | 2013-02-13 | — | — | EP | claimed |