Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | MEN1 | O00255 | 7/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 4/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 4/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2599821 | 0.82 | TRIM24 (0.42) | ALDH1A1MEN1KMT2ASMN1; SMN2IMPDH2 | |
| SCHEMBL2599810 | 0.81 | ALDH1A1 (0.40) | ALDH1A1MEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL838056 | 0.80 | ALDH1A1 (0.54) | ALDH1A1MEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL12182595 | 0.77 | TDP1 (0.34) | ALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL2599736 | 0.77 | ERN1 (0.40) | ALDH1A1MEN1KMT2ASMN1; SMN2IMPDH2 | |
| SCHEMBL2599729 | 0.77 | ALDH1A1 (0.46) | ALDH1A1MEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL2599761 | 0.77 | ALDH1A1 (0.33) | ALDH1A1MEN1KMT2ASMN1; SMN2TDP1 | |
| SCHEMBL31357864 | 0.77 | CYP1A2 (0.35) | ALDH1A1LMNACYP1A2CYP2A6 | |
| SCHEMBL22955073 | 0.76 | ALDH1A1 (0.39) | ALDH1A1MEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL2599758 | 0.76 | PARP1 (0.36) | ALDH1A1MEN1KMT2AIMPDH2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130040978-A1 | SPIRO ISOXAZOLINE COMPOUNDS AS SSTR5 ANTAGONISTS | MERCK SHARP & DOHME CORP | 2013-02-14 | — | — | US | disclosed |
| US-20130040978-A1 | SPIRO ISOXAZOLINE COMPOUNDS AS SSTR5 ANTAGONISTS | MERCK SHARP & DOHME CORP | 2013-02-14 | — | — | US | disclosed |
| US-20130040978-A1 | SPIRO ISOXAZOLINE COMPOUNDS AS SSTR5 ANTAGONISTS | MERCK SHARP & DOHME CORP | 2013-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130040978-A1 | SPIRO ISOXAZOLINE COMPOUNDS AS SSTR5 ANTAGONISTS | SSTR5, SSTR2, SSTR1 | ALDH1A1 1103/4885MEN1 1411/4885KMT2A 3652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.