Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HTT | P42858 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17829706 | 0.80 | SMN1; SMN2 (0.49) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL838056 | 0.80 | ALDH1A1 (0.54) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL17829640 | 0.79 | ALDH1A1 (0.52) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL17829698 | 0.78 | ALDH1A1 (0.50) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL14689705 | 0.77 | ALDH1A1 (0.40) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL17829727 | 0.77 | ALDH1A1 (0.51) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL31516344 | 0.75 | POLB (0.62) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL14448832 | 0.75 | POLB (0.62) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL17829730 | 0.75 | ALDH1A1 (0.50) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL22955073 | 0.73 | ALDH1A1 (0.39) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011146324-A1 | SPIRO ISOXAZOLINE COMPOUNDS AS SSTR5 ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2011-11-24 | — | — | WO | disclosed |