Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.46 |
| ▸ | SCD | O00767 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | GPR6 | P46095 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1550949 | 0.93 | GPR119 (0.51) | GPR119SCDNPC1MAPTHTT | |
| SCHEMBL2539391 | 0.91 | GPR119 (0.44) | GPR119SCDNPC1MAPTHTT | |
| SCHEMBL2542106 | 0.91 | GPR119 (0.44) | GPR119SCDNPC1MAPTHTT | |
| SCHEMBL14693050 | 0.89 | GPR119 (0.50) | GPR119SCDNPC1MAPTHTT | |
| SCHEMBL2545051 | 0.89 | GPR119 (0.56) | GPR119SCDNPC1MAPTHTT | |
| SCHEMBL1549889 | 0.89 | GPR119 (0.55) | GPR119SCDNPC1MAPTHTT | |
| SCHEMBL14693053 | 0.85 | GPR119 (0.43) | GPR119SCDKCNH2GPR6 | |
| SCHEMBL14693051 | 0.85 | GPR119 (0.57) | GPR119KCNH2 | |
| SCHEMBL2540230 | 0.81 | GPR119 (0.66) | GPR119KCNH2 | |
| SCHEMBL2541877 | 0.81 | BCAT1 (0.42) | SCDNPC1MAPTHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8372837-B2 | Pyridone and pyridazone analogues as GPR119 modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-02-12 | — | — | US | disclosed |