Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 14/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.46 |
| ▸ | KIT | P10721 | 3/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.46 |
| ▸ | RET | P07949 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.46 |
| ▸ | FLT1 | P17948 | 2/20 | 0.46 |
| ▸ | FLT4 | P35916 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | STK10 | O94804 | 1/20 | 0.46 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14693182 | 1.00 | FGFR4 (0.46) | FGFR4FGFR1FGFR2FGFR3KIT | |
| SCHEMBL1896693 | 0.91 | FGFR4 (0.47) | FGFR4FGFR1FGFR2FGFR3KIT | |
| SCHEMBL1896692 | 0.91 | FGFR4 (0.47) | FGFR4FGFR1FGFR2FGFR3KIT | |
| SCHEMBL14693153 | 0.91 | AXL (0.39) | FGFR4FGFR1FGFR2FGFR3KIT | |
| SCHEMBL1891662 | 0.91 | FGFR4 (0.57) | FGFR4FGFR1FGFR2FGFR3KIT | |
| SCHEMBL1891658 | 0.91 | FGFR4 (0.57) | FGFR4FGFR1FGFR2FGFR3KIT | |
| SCHEMBL14693152 | 0.90 | MET (0.39) | FGFR1FGFR2KITPDGFRARET | |
| SCHEMBL14693165 | 0.89 | FGFR4 (0.59) | FGFR4FGFR1FGFR2FGFR3KIT | |
| SCHEMBL14693168 | 0.89 | FGFR4 (0.47) | FGFR4FGFR1FGFR2FGFR3KIT | |
| SCHEMBL1893320 | 0.86 | FGFR4 (0.41) | FGFR4FGFR1FGFR2FGFR3KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8372981-B2 | Nitrogen-containing aromatic derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-02-12 | — | — | US | disclosed |