Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 7/20 | 0.39 |
| ▸ | AXL | P30530 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 14/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 10/20 | 0.38 |
| ▸ | KIT | P10721 | 3/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 5/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.37 |
| ▸ | FLT4 | P35916 | 3/20 | 0.37 |
| ▸ | FLT3 | P36888 | 3/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.37 |
| ▸ | AURKA | O14965 | 3/20 | 0.37 |
| ▸ | TEK | Q02763 | 3/20 | 0.37 |
| ▸ | CSF1R | P07333 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 4/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.36 |
| ▸ | STK10 | O94804 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | LYN | P07948 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14693153 | 0.94 | AXL (0.39) | METAXLKDRPDGFRAKIT | |
| SCHEMBL12673908 | 0.91 | KDR (0.46) | METAXLKDRPDGFRAKIT | |
| SCHEMBL14693182 | 0.90 | FGFR4 (0.46) | METAXLKDRPDGFRAKIT | |
| SCHEMBL14693151 | 0.90 | FGFR4 (0.46) | METAXLKDRPDGFRAKIT | |
| SCHEMBL1897137 | 0.90 | KDR (0.46) | METAXLKDRPDGFRAKIT | |
| SCHEMBL1897135 | 0.90 | KDR (0.46) | METAXLKDRPDGFRAKIT | |
| SCHEMBL14693181 | 0.89 | KDR (0.45) | METAXLKDRPDGFRAKIT | |
| SCHEMBL14693166 | 0.88 | KDR (0.40) | METAXLKDRPDGFRAKIT | |
| SCHEMBL14693175 | 0.85 | KDR (0.43) | METAXLKDRPDGFRAKIT | |
| SCHEMBL14437845 | 0.84 | MET (0.36) | METAXLKDRPDGFRAFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8372981-B2 | Nitrogen-containing aromatic derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-02-12 | — | — | US | disclosed |