Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 7/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.35 |
| ▸ | BTK | Q06187 | 3/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HCK | P08631 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14693524 | 0.82 | SRC (0.58) | SRCEGFRHDAC1BTKJAK3 | |
| SCHEMBL14693570 | 0.71 | SRC (0.54) | SRCEGFRHDAC1BTKABL1 | |
| SCHEMBL14693569 | 0.71 | SRC (0.54) | SRCEGFRHDAC1BTKABL1 | |
| SCHEMBL14706394 | 0.68 | SRC (0.46) | SRCEGFRBTKJAK3ABL1 | |
| SCHEMBL14693536 | 0.68 | SRC (0.50) | SRCEGFRHDAC1BTKABL1 | |
| SCHEMBL14693535 | 0.68 | SRC (0.50) | SRCEGFRHDAC1BTKABL1 | |
| SCHEMBL14693476 | 0.67 | JAK3 (0.39) | SRCEGFRBTKJAK3LCK | |
| SCHEMBL15165325 | 0.66 | JAK3 (0.35) | SRCEGFRBTKJAK3FGFR4 | |
| SCHEMBL7779064 | 0.65 | HTR3E (0.54) | BTKFGFR4KMT2ABCL2A1 | |
| SCHEMBL15143859 | 0.64 | BTK (0.59) | SRCEGFRBTKJAK3HCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8377946-B1 | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors | PHARMACYCLICS, INC. (US) | 2013-02-19 | — | — | US | disclosed |